Human organoids, self-organized and differentiated from homogenous pluripotent stem cells
(PSC), replicate the key structural and functional characteristics of their in vivo counterparts …

Recreating human organ–level function in vitro is a rapidly evolving field that integrates
tissue engineering, stem cell biology, and microfluidic technology to produce 3D organoids …

Current in-vitro 2D cultures and animal models present severe limitations in recapitulating
human physiopathology with striking discrepancies in estimating drug efficacy and side …

While considerable progress has been made in studying genetic and cellular aspects of
metastasis with in vitro cell culture and in vivo animal models, the driving mechanisms of …

The increasing insight into the molecular and cellular processes within the angiogenic
cascade assists in enhancing the survival and integration of engineered bone constructs …

Microphysiological systems (MPSs) with three-dimensional (3D) cultured models have
attracted considerable interest because of their potential to mimic human health and disease …

A major deficit in tissue engineering strategies is the lack of materials that promote
angiogenesis, wherein endothelial cells from the host vasculature invade the implanted …

Cardiac organoids are 3-dimensional (3D) structures composed of tissue or niche-specific
cells, obtained from diverse sources, encapsulated in either a naturally derived or synthetic …

Radiation therapy for head and neck cancers causes salivary gland dysfunction leading to
permanent xerostomia. Limited progress in the discovery of new therapeutic strategies is …

Tissue engineering is a rapidly developing field with many potential clinical applications in
tissue and organ regeneration. The development of a mature and stable vasculature within …