The activity-regulated cytoskeletal (Arc) gene encodes a protein that is critical for memory
consolidation. Arc is one of the most tightly regulated molecules known: neuronal activity …

Immediate-early genes (IEGs) are rapidly activated after sensory and behavioral experience
and are believed to be crucial for converting experience into long-term memory. Neuronal …

A vast number of different neuronal activity patterns could each induce a different set of
activity-regulated genes. Mapping this coupling between activity pattern and gene induction …

Enhancer RNAs (eRNAs) are a class of long noncoding RNAs (lncRNA) expressed from
active enhancers, whose function and action mechanism are yet to be firmly established …

Activity-driven transcription plays an important role in many brain processes, including those
underlying memory and epilepsy. Here we combine genetic tagging of nuclei and ribosomes …

Precise regulation of transcription is crucial for the cellular mechanisms underlying memory
formation. However, the link between neuronal stimulation and the proteins that directly …

Neuronal activity-inducible gene transcription correlates with rapid and transient increases
in histone acetylation at promoters and enhancers of activity-regulated genes. Exactly how …

Background A wide variety of bacterial species produces protease enzyme, and the
application of the same enzyme has been manipulated precisely and used in various …

Elevated extracellular potassium chloride is widely used to achieve membrane
depolarization of cultured neurons. This technique has illuminated mechanisms of calcium …

Promoter-proximal pausing by RNA polymerase II (Pol II) is a well-established mechanism to
control the timing, rate, and possibly the magnitude of transcriptional responses. Recent …