Primary cilia are microtubule-based, non-motile sensory organelles present in most types of
growth-arrested eukaryotic cells. They are transduction hubs that receive and transmit …

cAMP is a universal second messenger that relies on precise spatio-temporal regulation to
control varied, and often opposing, cellular functions. This is achieved via selective …

Bardet‐Biedl syndrome (BBS) is a ciliopathy characterized by retinal degeneration, obesity,
renal abnormalities, postaxial polydactyly, and developmental defects. Genes mutated in …

Dysfunction of cell cycle control and defects of primary ciliogenesis are two features of many
cancers. Whether these events are interconnected and the driving mechanism coordinating …

Abstract The Sonic Hedgehog (Hh) signal transduction pathway plays a critical role in many
developmental processes and, when deregulated, may contribute to several cancers …

Clear cell renal cell carcinoma (ccRCC) is the most common kidney cancer in the adult
population. Late diagnosis, resistance to therapeutics and recurrence of metastatic lesions …

Glioblastoma multiforme (GBM) is the most frequent and aggressive form of primary brain
tumor in the adult population; its high recurrence rate and resistance to current therapeutics …

The maintenance of cellular homeostasis in response to extracellular stimuli, ie, nutrient and
hormone signaling, hypoxia, or mechanical forces by autophagy, is vital for the health of …

The Praja family is an E3 ubiquitin ligase, promoting polyubiquitination and subsequent
degradation of substrates. It comprises two paralogs, praja1 and praja2. Prior research …

Cellular processes are highly dependent on a dynamic proteome that undergoes structural
and functional rearrangements to allow swift conversion between different cellular states. By …