The liver performs numerous vital functions, including the detoxification of blood before
access to the brain while simultaneously secreting and internalizing scores of proteins and …

Heavy alcohol use is the cause of alcoholic liver disease (ALD). The ALD spectrum ranges
from alcoholic steatosis to steatohepatitis, fibrosis, and cirrhosis. In Western countries …

Lipid droplet (LD) catabolism in hepatocytes is mediated by a combination of lipolysis and a
selective autophagic mechanism called lipophagy, but the relative contributions of these …

Hepatocytes metabolize energy-rich cytoplasmic lipid droplets (LDs) in the lysosome-
directed process of autophagy. An organelle-selective form of this process (macrolipophagy) …

Oncogene-induced metabolic reprogramming is a hallmark of pancreatic cancer (PDAC), yet
the metabolic drivers of metastasis are unclear. In PDAC, obesity and excess fatty acids …

When the brain is in a pathological state, the content of lipid droplets (LDs), the lipid storage
organelles, is increased, particularly in glial cells, but rarely in neurons. The biology and …

In recent years, increasing evidence regarding the functional importance of lipid droplets
(LDs), cytoplasmic storage organelles in the central nervous system (CNS), has emerged …

Accumulating evidence suggests that chronic stress could perturb the composition of the gut
microbiota and induce host anxiety-and depression-like behaviors. In particular …

Several studies have shown that blood vitamin levels are low in alcoholic patients. In effect,
alcohol use abuse is considered a chronic disease that promotes the pathogenesis of many …

Chronic alcohol consumption often induces hepatic steatosis but rarely causes severe
inflammation in Kupffer cells (KCs) despite the increased hepatic influx of …