[HTML][HTML] Beyond the Cell: The cell biology of the hepatocyte: A membrane trafficking machine
The liver performs numerous vital functions, including the detoxification of blood before
access to the brain while simultaneously secreting and internalizing scores of proteins and …
access to the brain while simultaneously secreting and internalizing scores of proteins and …
[HTML][HTML] Alcoholic liver disease: A current molecular and clinical perspective
K Ohashi, M Pimienta, E Seki - Liver research, 2018 - Elsevier
Heavy alcohol use is the cause of alcoholic liver disease (ALD). The ALD spectrum ranges
from alcoholic steatosis to steatohepatitis, fibrosis, and cirrhosis. In Western countries …
from alcoholic steatosis to steatohepatitis, fibrosis, and cirrhosis. In Western countries …
[HTML][HTML] Lipid droplet size directs lipolysis and lipophagy catabolism in hepatocytes
MB Schott, SG Weller, RJ Schulze… - The Journal of cell …, 2019 - ncbi.nlm.nih.gov
Lipid droplet (LD) catabolism in hepatocytes is mediated by a combination of lipolysis and a
selective autophagic mechanism called lipophagy, but the relative contributions of these …
selective autophagic mechanism called lipophagy, but the relative contributions of these …
Direct lysosome-based autophagy of lipid droplets in hepatocytes
RJ Schulze, EW Krueger, SG Weller… - Proceedings of the …, 2020 - National Acad Sciences
Hepatocytes metabolize energy-rich cytoplasmic lipid droplets (LDs) in the lysosome-
directed process of autophagy. An organelle-selective form of this process (macrolipophagy) …
directed process of autophagy. An organelle-selective form of this process (macrolipophagy) …
KRAS controls pancreatic cancer cell lipid metabolism and invasive potential through the lipase HSL
CN Rozeveld, KM Johnson, L Zhang, GL Razidlo - Cancer research, 2020 - AACR
Oncogene-induced metabolic reprogramming is a hallmark of pancreatic cancer (PDAC), yet
the metabolic drivers of metastasis are unclear. In PDAC, obesity and excess fatty acids …
the metabolic drivers of metastasis are unclear. In PDAC, obesity and excess fatty acids …
Astrocytes in stress accumulate lipid droplets
T Smolič, P Tavčar, A Horvat, U Černe… - Glia, 2021 - Wiley Online Library
When the brain is in a pathological state, the content of lipid droplets (LDs), the lipid storage
organelles, is increased, particularly in glial cells, but rarely in neurons. The biology and …
organelles, is increased, particularly in glial cells, but rarely in neurons. The biology and …
Pathophysiology of lipid droplets in neuroglia
In recent years, increasing evidence regarding the functional importance of lipid droplets
(LDs), cytoplasmic storage organelles in the central nervous system (CNS), has emerged …
(LDs), cytoplasmic storage organelles in the central nervous system (CNS), has emerged …
Gut microbiome-derived lactate promotes to anxiety-like behaviors through GPR81 receptor-mediated lipid metabolism pathway
B Shan, Z Ai, S Zeng, Y Song, J Song, Q Zeng… - …, 2020 - Elsevier
Accumulating evidence suggests that chronic stress could perturb the composition of the gut
microbiota and induce host anxiety-and depression-like behaviors. In particular …
microbiota and induce host anxiety-and depression-like behaviors. In particular …
[HTML][HTML] Vitamin supplements as a nutritional strategy against chronic alcohol consumption? an updated review
Several studies have shown that blood vitamin levels are low in alcoholic patients. In effect,
alcohol use abuse is considered a chronic disease that promotes the pathogenesis of many …
alcohol use abuse is considered a chronic disease that promotes the pathogenesis of many …
Catecholamine induces Kupffer cell apoptosis via growth differentiation factor 15 in alcohol-associated liver disease
Chronic alcohol consumption often induces hepatic steatosis but rarely causes severe
inflammation in Kupffer cells (KCs) despite the increased hepatic influx of …
inflammation in Kupffer cells (KCs) despite the increased hepatic influx of …