Human diseases, particularly infectious diseases and cancers, pose unprecedented
challenges to public health security and the global economy. The development and …

With the accumulation of mutations in SARS-CoV-2 and the continuous emergence of new
variants, the importance of developing safer and effective vaccines has become more …

The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
the main target for neutralizing antibodies (NAbs). The S protein trimer is anchored in the …

Rapid development of COVID-19 vaccines has helped mitigating SARS-CoV-2 spread, but
more equitable allocation of vaccines is necessary to limit the global impact of the COVID-19 …

Safe and effective vaccines are the best method to defeat worldwide SARS-CoV-2 and its
circulating variants. The SARS-CoV-2 S protein and its subunits are the most attractive …

With the rapid increase in SARS-CoV-2 cases in children, a safe and effective vaccine for
this population is urgently needed. The MMR (measles/mumps/rubella) vaccine has been …

Summary Background V591 (TMV-083) is a live recombinant measles vector-based vaccine
candidate expressing a pre-fusion stabilized SARS-CoV-2 spike protein. Methods We …

Using viruses to our advantage has been a huge leap for humanity. Their ability to mediate
horizontal gene transfer has made them useful tools for gene therapy, vaccine development …

Recombinant protein approaches offer major promise for safe and effective vaccine
prevention of SARS-CoV-2 infection. We developed a recombinant spike protein vaccine …

Several COVID-19 vaccines have now been deployed to tackle the SARS-CoV-2 pandemic,
most of them based on messenger RNA or adenovirus vectors. The duration of protection …