[HTML][HTML] Beyond IDH-mutation: emerging molecular diagnostic and prognostic features in adult diffuse gliomas
K Mirchia, TE Richardson - Cancers, 2020 - mdpi.com
Diffuse gliomas are among the most common adult central nervous system tumors with an
annual incidence of more than 16,000 cases in the United States. Until very recently, the …
annual incidence of more than 16,000 cases in the United States. Until very recently, the …
[HTML][HTML] Chromosomal instability in adult-type diffuse gliomas
TE Richardson, JM Walker, KG Abdullah… - Acta Neuropathologica …, 2022 - Springer
Chromosomal instability (CIN) is a fundamental property of cancer and a key underlying
mechanism of tumorigenesis and malignant progression, and has been documented in a …
mechanism of tumorigenesis and malignant progression, and has been documented in a …
Efficacy of laser interstitial thermal therapy (LITT) for newly diagnosed and recurrent IDH wild-type glioblastoma
Background Treatment options for unresectable new and recurrent glioblastoma remain
limited. Laser ablation has demonstrated safety as a surgical approach to treating primary …
limited. Laser ablation has demonstrated safety as a surgical approach to treating primary …
[HTML][HTML] A novel prognostic tool for glioma based on enhancer RNA-regulated immune genes
W Tian, K Chen, G Yan, X Han, Y Liu… - Frontiers in Cell and …, 2022 - frontiersin.org
Background: Gliomas are the most malignant tumors of the nervous system. Even though
their survival outcome is closely affected by immune-related genes (IRGs) in the tumor …
their survival outcome is closely affected by immune-related genes (IRGs) in the tumor …
[HTML][HTML] Simple approach for the histomolecular diagnosis of central nervous system gliomas based on 2021 World Health Organization Classification
The classification of central nervous system (CNS) glioma went through a sequence of
developments, between 2006 and 2021, started with only histological approach then has …
developments, between 2006 and 2021, started with only histological approach then has …
[HTML][HTML] Global DNA methylation profiling reveals chromosomal instability in IDH-mutant astrocytomas
Diffusely infiltrating gliomas are among the most common central nervous system tumors in
adults. Over the past decade, the subcategorization of these tumors has changed to include …
adults. Over the past decade, the subcategorization of these tumors has changed to include …
The role of RB1 alteration and 4q12 amplification in IDH-WT glioblastoma
Background Recent studies have identified that glioblastoma IDH-wildtype (GBM IDH-WT)
might be comprised of molecular subgroups with distinct prognoses. Therefore, we …
might be comprised of molecular subgroups with distinct prognoses. Therefore, we …
Molecular characterization of “true” low-grade IDH-wildtype astrocytomas
TE Richardson, KJ Hatanpaa… - … of Neuropathology & …, 2021 - academic.oup.com
Numerous recent studies have demonstrated that the vast majority of IDH-wildtype
astrocytomas with WHO grade II/III histology have clinical outcomes equivalent to IDH …
astrocytomas with WHO grade II/III histology have clinical outcomes equivalent to IDH …
[HTML][HTML] Machine learning modeling of genome-wide copy number alteration signatures reliably predicts IDH mutational status in adult diffuse glioma
Abstract Knowledge of 1p/19q-codeletion and IDH1/2 mutational status is necessary to
interpret any investigational study of diffuse gliomas in the modern era. While DNA …
interpret any investigational study of diffuse gliomas in the modern era. While DNA …
Molecular signatures of chromosomal instability correlate with copy number variation patterns and patient outcome in IDH-mutant and IDH-wildtype astrocytomas
Chromosomal instability due to mutations in genes guarding the stability of the genome is a
well-known mechanism underlying tumorigenesis and malignant progression in numerous …
well-known mechanism underlying tumorigenesis and malignant progression in numerous …