Traditionally, multiple sclerosis has been categorised by distinct clinical descriptors—
relapsing-remitting, secondary progressive, and primary progressive—for patient care …

The myelination of axons by oligodendrocytes is a highly complex cell-to-cell interaction.
Oligodendrocytes and axons have a reciprocal signaling relationship in which …

Oligodendrocyte loss in neurological disease leaves axons vulnerable to damage and
degeneration, and activity-dependent myelination may represent an endogenous …

Cortical pathology contributes to chronic cognitive impairment of patients suffering from the
neuroinflammatory disease multiple sclerosis (MS). How such gray matter inflammation …

Saltatory conduction of action potentials along myelinated axons depends on the nodes of
Ranvier—small unmyelinated axonal domains where voltage-gated sodium channels are …

SARM1 is an inducible NAD+ hydrolase that triggers axon loss and neuronal cell death in
the injured and diseased nervous system. While SARM1 activation and enzyme function are …

Objective Multiple sclerosis (MS) is a chronic neuroinflammatory and neurodegenerative
disease of unknown etiology. Although the prevalent view regards a CD4+‐lymphocyte …

Oligodendrocyte progenitor cells (OPCs) are the most proliferative and dispersed population
of progenitor cells in the adult central nervous system, which allows these cells to rapidly …

Plasma membrane integrity is essential for cellular homeostasis. In vivo, cells experience
plasma membrane damage from a multitude of stressors in the extra-and intra-cellular …

Abstract Purpose of Review Multiple sclerosis (MS) is the most common demyelinating
disease of the central nervous system (CNS). Inflammatory attacks in MS lead to both …