Higher-order organization of biomolecular condensates

CM Fare, A Villani, LE Drake, J Shorter - Open biology, 2021 - royalsocietypublishing.org
A guiding principle of biology is that biochemical reactions must be organized in space and
time. One way this spatio-temporal organization is achieved is through liquid–liquid phase …

Redox dysregulation as a driver for DNA damage and its relationship to neurodegenerative diseases

S Shadfar, S Parakh, MS Jamali, JD Atkin - Translational …, 2023 - Springer
Redox homeostasis refers to the balance between the production of reactive oxygen species
(ROS) as well as reactive nitrogen species (RNS), and their elimination by antioxidants. It is …

Single-cell genomic profiling of human dopamine neurons identifies a population that selectively degenerates in Parkinson's disease

T Kamath, A Abdulraouf, SJ Burris, J Langlieb… - Nature …, 2022 - nature.com
The loss of dopamine (DA) neurons within the substantia nigra pars compacta (SNpc) is a
defining pathological hallmark of Parkinson's disease (PD). Nevertheless, the molecular …

Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration

DV Neel, H Basu, G Gunner, MD Bergstresser… - Neuron, 2023 - cell.com
Mitochondrial dysfunction and axon loss are hallmarks of neurologic diseases. Gasdermin
(GSDM) proteins are executioner pore-forming molecules that mediate cell death, yet their …

PIKFYVE inhibition mitigates disease in models of diverse forms of ALS

ST Hung, GR Linares, WH Chang, Y Eoh, G Krishnan… - Cell, 2023 - cell.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that results from
many diverse genetic causes. Although therapeutics specifically targeting known causal …

Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells

F Tian, Y Cheng, S Zhou, Q Wang, A Monavarfeshani… - Neuron, 2022 - cell.com
Regulatory programs governing neuronal death and axon regeneration in
neurodegenerative diseases remain poorly understood. In adult mice, optic nerve crush …

Nucleolar stress: From development to cancer

MC Lafita-Navarro, M Conacci-Sorrell - Seminars in cell & developmental …, 2023 - Elsevier
The nucleolus is a large nuclear membraneless organelle responsible for ribosome
biogenesis. Ribosomes are cytoplasmic macromolecular complexes comprising RNA and …

Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology

OJ Ziff, J Neeves, J Mitchell, G Tyzack… - Nature …, 2023 - nature.com
Abstract Amyotrophic Lateral Sclerosis (ALS) causes motor neuron degeneration, with 97%
of cases exhibiting TDP-43 proteinopathy. Elucidating pathomechanisms has been …

Recurrent repeat expansions in human cancer genomes

GS Erwin, G Gürsoy, R Al-Abri, A Suriyaprakash… - Nature, 2023 - nature.com
Expansion of a single repetitive DNA sequence, termed a tandem repeat (TR), is known to
cause more than 50 diseases,. However, repeat expansions are often not explored beyond …

[HTML][HTML] Human stem cell models of neurodegeneration: From basic science of amyotrophic lateral sclerosis to clinical translation

E Giacomelli, BF Vahsen, EL Calder, Y Xu, J Scaber… - Cell Stem Cell, 2022 - cell.com
Neurodegenerative diseases are characterized by progressive cell loss leading to disruption
of the structure and function of the central nervous system. Amyotrophic lateral sclerosis …