Higher-order organization of biomolecular condensates
A guiding principle of biology is that biochemical reactions must be organized in space and
time. One way this spatio-temporal organization is achieved is through liquid–liquid phase …
time. One way this spatio-temporal organization is achieved is through liquid–liquid phase …
Redox dysregulation as a driver for DNA damage and its relationship to neurodegenerative diseases
Redox homeostasis refers to the balance between the production of reactive oxygen species
(ROS) as well as reactive nitrogen species (RNS), and their elimination by antioxidants. It is …
(ROS) as well as reactive nitrogen species (RNS), and their elimination by antioxidants. It is …
Single-cell genomic profiling of human dopamine neurons identifies a population that selectively degenerates in Parkinson's disease
T Kamath, A Abdulraouf, SJ Burris, J Langlieb… - Nature …, 2022 - nature.com
The loss of dopamine (DA) neurons within the substantia nigra pars compacta (SNpc) is a
defining pathological hallmark of Parkinson's disease (PD). Nevertheless, the molecular …
defining pathological hallmark of Parkinson's disease (PD). Nevertheless, the molecular …
Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration
Mitochondrial dysfunction and axon loss are hallmarks of neurologic diseases. Gasdermin
(GSDM) proteins are executioner pore-forming molecules that mediate cell death, yet their …
(GSDM) proteins are executioner pore-forming molecules that mediate cell death, yet their …
PIKFYVE inhibition mitigates disease in models of diverse forms of ALS
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that results from
many diverse genetic causes. Although therapeutics specifically targeting known causal …
many diverse genetic causes. Although therapeutics specifically targeting known causal …
Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells
Regulatory programs governing neuronal death and axon regeneration in
neurodegenerative diseases remain poorly understood. In adult mice, optic nerve crush …
neurodegenerative diseases remain poorly understood. In adult mice, optic nerve crush …
Nucleolar stress: From development to cancer
MC Lafita-Navarro, M Conacci-Sorrell - Seminars in cell & developmental …, 2023 - Elsevier
The nucleolus is a large nuclear membraneless organelle responsible for ribosome
biogenesis. Ribosomes are cytoplasmic macromolecular complexes comprising RNA and …
biogenesis. Ribosomes are cytoplasmic macromolecular complexes comprising RNA and …
Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology
Abstract Amyotrophic Lateral Sclerosis (ALS) causes motor neuron degeneration, with 97%
of cases exhibiting TDP-43 proteinopathy. Elucidating pathomechanisms has been …
of cases exhibiting TDP-43 proteinopathy. Elucidating pathomechanisms has been …
Recurrent repeat expansions in human cancer genomes
Expansion of a single repetitive DNA sequence, termed a tandem repeat (TR), is known to
cause more than 50 diseases,. However, repeat expansions are often not explored beyond …
cause more than 50 diseases,. However, repeat expansions are often not explored beyond …
[HTML][HTML] Human stem cell models of neurodegeneration: From basic science of amyotrophic lateral sclerosis to clinical translation
Neurodegenerative diseases are characterized by progressive cell loss leading to disruption
of the structure and function of the central nervous system. Amyotrophic lateral sclerosis …
of the structure and function of the central nervous system. Amyotrophic lateral sclerosis …