This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Ion channels play a central role in the regulation of nearly every cellular process. Dating
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …

Vasculogenesis, angiogenesis and arteriogenesis represent three crucial mechanisms
involved in the formation and maintenance of the vascular network in embryonal and post …

Biological tissues are fed by arterial networks whose task is to set blood flow delivery in
accordance with energetic demand. Coordinating vasomotor activity among hundreds of …

Background: Neurovascular coupling (NVC) is the mechanism whereby an increase in
neuronal activity (NA) leads to local elevation in cerebral blood flow (CBF) to match the …

Transient receptor potential (TRP) ion channels were first characterized on neurons, where
they are classically implicated in sensory functions; however, research in recent decades …

Hypoxia and ischemia are linked to oxidative stress, which can activate the oxidant-sensitive
transient receptor potential ankyrin 1 (TRPA1) channel in cerebral artery endothelial cells …

The vascular endothelium is a broadly distributed and highly specialized organ. The
endothelium has a number of functions including the control of blood vessels diameter …

Small arteries in the body control vascular resistance, and therefore, blood pressure and
blood flow. Endothelial and smooth muscle cells in the arterial walls respond to various …

Background Recent studies demonstrate that spatially restricted, local Ca2+ signals are key
regulators of endothelium‐dependent vasodilation in systemic circulation. There are drastic …