Highlights•A new zinc metallothionein in Drosophila is identified.•Zinc regulates the
functional integrity of secretory pathway and cell signaling.•Intracellular iron and zinc …

TANGO1 protein facilitates the endoplasmic reticulum (ER) export of large cargoes that
cannot be accommodated in 60 nm transport vesicles. It assembles into a ring in the plane of …

At the trans-Golgi, complex traffic connections exist to the endolysosomal system additional
to the main Golgi-to–plasma membrane secretory route. Here, we investigated three hits in a …

Secretory cargos are collected at endoplasmic reticulum (ER) exit sites (ERES) before
transport to the Golgi apparatus. Decades of research have provided many details of the …

The evolution of basement membranes (BMs) played an essential role in the organization of
animal cells into tissues and diversification of body plans. The archetypal BM is a compact …

Regulated secretion is a conserved process occurring across diverse cells and tissues.
Current models suggest that the conserved cargo receptor Tango1 mediates the packaging …

Selective autophagy receptors and adapters contain short linear motifs called LIR motifs
(LC3-interacting region), which are required for the interaction with the Atg8-family proteins …

The Golgi is the central sorting station in the secretory pathway and thus the destination of
transport vesicles arriving from the endoplasmic reticulum and endosomes and from within …

Amyloid β (Aβ) accumulation is a hallmark of Alzheimer's disease. In adult Drosophila
brains, human Aβ overexpression harms climbing and lifespan. It's uncertain whether Aβ is …

Type I collagen is an important structural protein of bone, skin, tendon, ligament and other
connective tissues. It is initially synthesized as a precursor form, procollagen, consisting of …