Structural diversity and biological activities of phloroglucinol derivatives from Hypericum species

H Bridi, G de Carvalho Meirelles, GL von Poser - Phytochemistry, 2018 - Elsevier
Plants of the genus Hypericum (Hypericaceae) are used in folk medicine all over the world,
H. perforatum being the most well-known species. Standardized extracts of this plant are …

Determination of Potential Drug Candidate Molecules of the Hypericum perforatum for COVID-19 Treatment

S Yalçın, S Yalçınkaya, F Ercan - Current pharmacology reports, 2021 - Springer
The novel human coronavirus was firstly emerged in December 2019 in Wuhan, China, and
has spread rapidly around the world. There is no known specific effective treatment of …

Cytotoxic and apoptogenic effect of hypericin, the bioactive component of Hypericum perforatum on the MCF-7 human breast cancer cell line

SA Mirmalek, MA Azizi, E Jangholi… - Cancer cell …, 2015 - Springer
Background Breast cancer is the most prevalent malignancies among the women that have
a high mortality. Previous studies demonstrated that hypericin, a bioactive component of …

Chemical Characterization and Antioxidant Activity of Nine Hypericum Species from Greece

E Kakouri, P Trigas, D Daferera, E Skotti, PA Tarantilis… - Antioxidants, 2023 - mdpi.com
Hypericum L. comprises about 500 species distributed almost worldwide. Research has
mainly focused on H. perforatum with confirmed biological activity on the alleviation of …

Antiproliferative Effects of St. John's Wort, Its Derivatives, and Other Hypericum Species in Hematologic Malignancies

A Allegra, A Tonacci, EV Spagnolo, C Musolino… - International Journal of …, 2020 - mdpi.com
Hypericum is a widely present plant, and extracts of its leaves, flowers, and aerial elements
have been employed for many years as therapeutic cures for depression, skin wounds, and …

[HTML][HTML] Morphological and phytochemical diversity among Hypericum species of the Mediterranean Basin

NM Nürk, SL Crockett - Medicinal and aromatic plant science and …, 2011 - ncbi.nlm.nih.gov
Abstract The genus Hypericum L.(St. John's wort, Hypericaceae) includes more than 450
species that occur in temperature or tropical mountain regions of the world. Monographic …

The Phytochemistry and Pharmacology of Hypericum

CY Xiao, Q Mu, S Gibbons - Progress in the chemistry of organic natural …, 2020 - Springer
Hypericum L. is a genus of the family Hypericaceae within the dicotyledones. The
constituents of Hypericum species are valued for their important biological properties. Their …

The Influence of Phytohormones on Antioxidative and Antibacterial Activities in Callus Cultures of Hypericum perforatum L.

I Jonuškienė, R Stankevičienė, K Kantminienė… - Agriculture, 2023 - mdpi.com
Natural extracts of Hypericum perforatum L. are widely used in the pharmaceutical industry
due to their antiviral, antioxidant, antibacterial, antidiabetic, and antidepressant activities …

Phloroglucinol derivatives from Hypericum empetrifolium with antiproliferative activity on endothelial cells

S Schmidt, G Jürgenliemk, H Skaltsa, J Heilmann - Phytochemistry, 2012 - Elsevier
Five acylphloroglucinols substituted with monoterpenoids (empetrifelixin A–D and
empetrikajaforin), three known monocyclic acylphloroglucinols and one monocyclic …

[PDF][PDF] Hypericin induces apoptosis in MDA-MB-175-VII cells in lower dose compared to MDA-MB-231

NA Gamasaee, M Radmansouri… - Archives of Iranian …, 2018 - journalaim.com
Background: Breast cancer is the major cause of death from cancer among women around
the world. Given the drug resistance in the treatment of this disease, it is very important to …