Chronic and cycling hypoxia: drivers of cancer chronic inflammation through HIF-1 and NF-κB activation: a review of the molecular mechanisms
J Korbecki, D Simińska… - International journal of …, 2021 - mdpi.com
Chronic (continuous, non-interrupted) hypoxia and cycling (intermittent, transient) hypoxia
are two types of hypoxia occurring in malignant tumors. They are both associated with the …
are two types of hypoxia occurring in malignant tumors. They are both associated with the …
Hypoxia-modified cancer cell metabolism
W Al Tameemi, TP Dale, RMK Al-Jumaily… - Frontiers in cell and …, 2019 - frontiersin.org
While oxygen is critical to the continued existence of complex organisms, extreme levels of
oxygen within a system, known as hypoxia (low levels of oxygen) and hyperoxia (excessive …
oxygen within a system, known as hypoxia (low levels of oxygen) and hyperoxia (excessive …
Lighting up the fire in the microenvironment of cold tumors: A major challenge to improve cancer immunotherapy
Immunotherapy includes immune checkpoint inhibitors (ICI) such as antibodies targeting
cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) or the programmed cell death …
cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) or the programmed cell death …
The role of hypoxia-inducible factors in cardiovascular diseases
B Yu, X Wang, Y Song, G Xie, S Jiao, L Shi… - Pharmacology & …, 2022 - Elsevier
Cardiovascular diseases are the leading cause of death worldwide. During the development
of cardiovascular diseases, hypoxia plays a crucial role. Hypoxia-inducible factors (HIFs) are …
of cardiovascular diseases, hypoxia plays a crucial role. Hypoxia-inducible factors (HIFs) are …
Hypoxia-inducible factor 3 biology: complexities and emerging themes
C Duan - American Journal of Physiology-Cell Physiology, 2016 - journals.physiology.org
The hypoxia-inducible factor (HIF) family has three distinct members in most vertebrates. All
three HIFs consist of a unique and oxygen-labile α-subunit and a common and stable β …
three HIFs consist of a unique and oxygen-labile α-subunit and a common and stable β …
Hypoxia, metabolism and immune cell function
E Krzywinska, C Stockmann - Biomedicines, 2018 - mdpi.com
Hypoxia is a hallmark of inflamed, infected or damaged tissue, and the adaptation to
inadequate tissue oxygenation is regulated by hypoxia-inducible factors (HIFs). HIFs are key …
inadequate tissue oxygenation is regulated by hypoxia-inducible factors (HIFs). HIFs are key …
Hypoxia and inflammation in cancer, focus on HIF and NF-κB
Cancer is often characterised by the presence of hypoxia and inflammation. Paramount to
the mechanisms controlling cellular responses under such stress stimuli, are the …
the mechanisms controlling cellular responses under such stress stimuli, are the …
Hypoxia dictates metabolic rewiring of tumors: implications for chemoresistance
DC Belisario, J Kopecka, M Pasino, M Akman… - Cells, 2020 - mdpi.com
Hypoxia is a condition commonly observed in the core of solid tumors. The hypoxia-
inducible factors (HIF) act as hypoxia sensors that orchestrate a coordinated response …
inducible factors (HIF) act as hypoxia sensors that orchestrate a coordinated response …
Crosstalk between hypoxia and ER stress response: a key regulator of macrophage polarization
P Díaz-Bulnes, ML Saiz, C López-Larrea… - Frontiers in …, 2020 - frontiersin.org
Macrophage activation and polarization are closely linked with metabolic rewiring, which is
required to sustain their biological functions. These metabolic alterations allow the …
required to sustain their biological functions. These metabolic alterations allow the …
The interplay between tumor suppressor p53 and hypoxia signaling pathways in cancer
Hypoxia is a hallmark of solid tumors and plays a critical role in different steps of tumor
progression, including proliferation, survival, angiogenesis, metastasis, metabolic …
progression, including proliferation, survival, angiogenesis, metastasis, metabolic …