Gastric carcinogenesis is a multistep process involving genetic and epigenetic alteration of
protein-coding proto-oncogenes and tumor-suppressor genes. Recent discoveries have …

Cancer is amongst the deadliest and most disruptive disorders, having a much higher death
rate than other diseases worldwide. Human cancer rates continue to rise, thereby posing the …

Clonal evolution is a key feature of cancer progression and relapse. We studied intratumoral
heterogeneity in 149 chronic lymphocytic leukemia (CLL) cases by integrating whole-exome …

The sphingolipid ceramide has been recognized as an important second messenger
implicated in regulating diverse signaling pathways especially for apoptosis. Very little is …

Abstract Arsenic trioxide (As 2 O 3) has shown considerable efficacy in treating
hematological malignancies with induction of programmed cell death (PCD) type I …

ICBP90, inverted CCAAT box-binding protein of 90 kDa, has been reported as a regulator of
topoisomerase IIα expression. We present evidence here that ICBP90 binds to methyl-CpG …

The incidence of gastroesophageal cancers is increasing each year, but despite much
research, their molecular mechanisms are incompletely understood. microRNAs (miRNAs) …

The BNIP3 subfamily of BH3-only proteins consists of BNIP3 and BNIP3-like (BNIP3L)
proteins. These proteins form stable homodimerization complexes that localize to the outer …

Since their discovery nearly 25 years ago, the BCL-2 family members BNIP3 and BNIP3L
(aka Nix) have been labelled 'atypical'. Originally, this was because BNIP3 and Nix have …

Activation of STAT3 in cancers leads to gene expression promoting cell proliferation and
resistance to apoptosis, as well as tumor angiogenesis, invasion, and migration. In the …