Marine natural products in clinical use
Marine natural products are potent and promising sources of drugs among other natural
products of plant, animal, and microbial origin. To date, 20 drugs from marine sources are in …
products of plant, animal, and microbial origin. To date, 20 drugs from marine sources are in …
Application of marine natural products in drug research
WY Lu, HJ Li, QY Li, YC Wu - Bioorganic & medicinal chemistry, 2021 - Elsevier
New diseases are emerging as the environment changes, so drug manufacturers are always
on the lookout for new resources to develop effective and safe drugs. In recent years, many …
on the lookout for new resources to develop effective and safe drugs. In recent years, many …
[HTML][HTML] Insights about clinically approved and Preclinically investigated marine natural products
Since the early research efforts focusing on bioactive marine substances such as
spongouridine, from the marine sponge Cryptotethya crypta, marine natural products …
spongouridine, from the marine sponge Cryptotethya crypta, marine natural products …
Perspectives and controversies regarding the use of natural products for the treatment of lung cancer
T Wen, L Song, S Hua - Cancer Medicine, 2021 - Wiley Online Library
Lung cancer is the leading cause of cancer‐related mortality both in men and women and
accounts for 18.4% of all cancer‐related deaths. Although advanced therapy methods have …
accounts for 18.4% of all cancer‐related deaths. Although advanced therapy methods have …
From life in the sea to the clinic: The marine drugs approved and under clinical trial
E Cappello, P Nieri - Life, 2021 - mdpi.com
In the last decades Blue Growth policy in european and non-european countries produced a
great impulse in applied marine sciences, comprehending the research of new bioactive …
great impulse in applied marine sciences, comprehending the research of new bioactive …
PeruNPDB: The Peruvian natural products database for in silico drug screening
HL Barazorda-Ccahuana, LG Ranilla… - Scientific Reports, 2023 - nature.com
Since the number of drugs based on natural products (NPs) represents a large source of
novel pharmacological entities, NPs have acquired significance in drug discovery. Peru is …
novel pharmacological entities, NPs have acquired significance in drug discovery. Peru is …
[HTML][HTML] Tubulin inhibitors. Selected scaffolds and main trends in the design of novel anticancer and antiparasitic agents
M Podolak, S Holota, Y Deyak, K Dziduch… - Bioorganic …, 2024 - Elsevier
Abstract Design of tubulin inhibitors as anticancer drugs dynamically developed over the
past 20 years. The modern arsenal of potential tubulin-targeting anticancer agents is …
past 20 years. The modern arsenal of potential tubulin-targeting anticancer agents is …
Comprehensive structure–activity relationship studies of macrocyclic natural products enabled by their total syntheses
H Itoh, M Inoue - Chemical reviews, 2019 - ACS Publications
Macrocyclic natural products have been recognized and utilized as new platforms for
designing drugs in pharmaceutical research because the constrained three-dimensional …
designing drugs in pharmaceutical research because the constrained three-dimensional …
[HTML][HTML] Virtual screening by targeting proteolytic sites of furin and TMPRSS2 to propose potential compounds obstructing the entry of SARS-CoV-2 virus into human …
Background and aim The year 2020 begins with the outbreak of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) that cause the disease COVID-19, and continue till …
syndrome coronavirus 2 (SARS-CoV-2) that cause the disease COVID-19, and continue till …
Eribulin penetrates brain tumor tissue and prolongs survival of mice harboring intracerebral glioblastoma xenografts
M Takahashi, S Miki, K Fujimoto, K Fukuoka… - Cancer …, 2019 - Wiley Online Library
Glioblastoma is one of the most devastating human malignancies for which a novel efficient
treatment is urgently required. This pre–clinical study shows that eribulin, a specific inhibitor …
treatment is urgently required. This pre–clinical study shows that eribulin, a specific inhibitor …