Marine natural products in clinical use

N Haque, S Parveen, T Tang, J Wei, Z Huang - Marine drugs, 2022 - mdpi.com
Marine natural products are potent and promising sources of drugs among other natural
products of plant, animal, and microbial origin. To date, 20 drugs from marine sources are in …

Application of marine natural products in drug research

WY Lu, HJ Li, QY Li, YC Wu - Bioorganic & medicinal chemistry, 2021 - Elsevier
New diseases are emerging as the environment changes, so drug manufacturers are always
on the lookout for new resources to develop effective and safe drugs. In recent years, many …

[HTML][HTML] Insights about clinically approved and Preclinically investigated marine natural products

MA Ghareeb, MA Tammam, A El-Demerdash… - Current Research in …, 2020 - Elsevier
Since the early research efforts focusing on bioactive marine substances such as
spongouridine, from the marine sponge Cryptotethya crypta, marine natural products …

Perspectives and controversies regarding the use of natural products for the treatment of lung cancer

T Wen, L Song, S Hua - Cancer Medicine, 2021 - Wiley Online Library
Lung cancer is the leading cause of cancer‐related mortality both in men and women and
accounts for 18.4% of all cancer‐related deaths. Although advanced therapy methods have …

From life in the sea to the clinic: The marine drugs approved and under clinical trial

E Cappello, P Nieri - Life, 2021 - mdpi.com
In the last decades Blue Growth policy in european and non-european countries produced a
great impulse in applied marine sciences, comprehending the research of new bioactive …

PeruNPDB: The Peruvian natural products database for in silico drug screening

HL Barazorda-Ccahuana, LG Ranilla… - Scientific Reports, 2023 - nature.com
Since the number of drugs based on natural products (NPs) represents a large source of
novel pharmacological entities, NPs have acquired significance in drug discovery. Peru is …

[HTML][HTML] Tubulin inhibitors. Selected scaffolds and main trends in the design of novel anticancer and antiparasitic agents

M Podolak, S Holota, Y Deyak, K Dziduch… - Bioorganic …, 2024 - Elsevier
Abstract Design of tubulin inhibitors as anticancer drugs dynamically developed over the
past 20 years. The modern arsenal of potential tubulin-targeting anticancer agents is …

Comprehensive structure–activity relationship studies of macrocyclic natural products enabled by their total syntheses

H Itoh, M Inoue - Chemical reviews, 2019 - ACS Publications
Macrocyclic natural products have been recognized and utilized as new platforms for
designing drugs in pharmaceutical research because the constrained three-dimensional …

[HTML][HTML] Virtual screening by targeting proteolytic sites of furin and TMPRSS2 to propose potential compounds obstructing the entry of SARS-CoV-2 virus into human …

S Vardhan, SK Sahoo - Journal of traditional and complementary medicine, 2022 - Elsevier
Background and aim The year 2020 begins with the outbreak of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) that cause the disease COVID-19, and continue till …

Eribulin penetrates brain tumor tissue and prolongs survival of mice harboring intracerebral glioblastoma xenografts

M Takahashi, S Miki, K Fujimoto, K Fukuoka… - Cancer …, 2019 - Wiley Online Library
Glioblastoma is one of the most devastating human malignancies for which a novel efficient
treatment is urgently required. This pre–clinical study shows that eribulin, a specific inhibitor …