[HTML][HTML] Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation
The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …
components across multiple spatial (from ion channel to organ) and temporal (from …
Atrial conduction velocity mapping: clinical tools, algorithms and approaches for understanding the arrhythmogenic substrate
Characterizing patient-specific atrial conduction properties is important for understanding
arrhythmia drivers, for predicting potential arrhythmia pathways, and for personalising …
arrhythmia drivers, for predicting potential arrhythmia pathways, and for personalising …
In vitro matured human pluripotent stem cell–derived cardiomyocytes form grafts with enhanced structure and function in injured hearts
W Dhahri, T Sadikov Valdman, D Wilkinson, E Pereira… - Circulation, 2022 - Am Heart Assoc
Background: Human pluripotent stem cell (hPSC)–derived cardiomyocytes (hPSC-CMs)
have tremendous promise for application in cardiac regeneration, but their translational …
have tremendous promise for application in cardiac regeneration, but their translational …
Slow conduction corridors and pivot sites characterize the electrical remodeling in atrial fibrillation
Objectives This study aimed to evaluate the progression of electrophysiological phenomena
in a cohort of patients with paroxysmal atrial fibrillation (PAF) and persistent atrial fibrillation …
in a cohort of patients with paroxysmal atrial fibrillation (PAF) and persistent atrial fibrillation …
Mechanism of ventricular tachycardia occurring in chronic myocardial infarction Scar
Cardiac arrest is the leading cause of death in the more economically developed countries.
Ventricular tachycardia associated with myocardial infarct is a prominent cause of cardiac …
Ventricular tachycardia associated with myocardial infarct is a prominent cause of cardiac …
OpenEP: a cross-platform electroanatomic mapping data format and analysis platform for electrophysiology research
Background Electroanatomic mapping systems are used to support electrophysiology
research. Data exported from these systems is stored in proprietary formats which are …
research. Data exported from these systems is stored in proprietary formats which are …
In silico evaluation of cell therapy in acute versus chronic infarction: role of automaticity, heterogeneity and Purkinje in human
Human-based modelling and simulation offer an ideal testbed for novel medical therapies to
guide experimental and clinical studies. Myocardial infarction (MI) is a common cause of …
guide experimental and clinical studies. Myocardial infarction (MI) is a common cause of …
Functional assessment of ventricular tachycardia circuits and their underlying substrate using automated conduction velocity mapping
Objectives This study sought to describe the utility of automated conduction velocity
mapping (ACVM) in ventricular tachycardia (VT) ablation. Background Identification of areas …
mapping (ACVM) in ventricular tachycardia (VT) ablation. Background Identification of areas …
A computational study of the electrophysiological substrate in patients suffering from atrial fibrillation
In the context of cardiac electrophysiology, we propose a novel computational approach to
highlight and explain the long-debated mechanisms behind atrial fibrillation (AF) and to …
highlight and explain the long-debated mechanisms behind atrial fibrillation (AF) and to …
Computational modeling of aberrant electrical activity following remuscularization with intramyocardially injected pluripotent stem cell-derived cardiomyocytes
KY Joseph, JA Liang, SH Weinberg… - Journal of molecular and …, 2022 - Elsevier
Acute engraftment arrhythmias (EAs) remain a serious complication of remuscularization
therapy. Preliminary evidence suggests that a focal source underlies these EAs stemming …
therapy. Preliminary evidence suggests that a focal source underlies these EAs stemming …