Pharmacokinetic principles in the inner ear: Influence of drug properties on intratympanic applications

AN Salt, SK Plontke - Hearing research, 2018 - Elsevier
Local drug delivery to the ear has gained wide clinical acceptance, with the choice of drug
and application protocol in humans largely empirically-derived. Here, we review the …

Biocompatible materials in otorhinolaryngology and their antibacterial properties

J Spałek, P Ociepa, P Deptuła, E Piktel… - International Journal of …, 2022 - mdpi.com
For decades, biomaterials have been commonly used in medicine for the replacement of
human body tissue, precise drug-delivery systems, or as parts of medical devices that are …

Controlled drug release to the inner ear: Concepts, materials, mechanisms, and performance

K Mäder, E Lehner, A Liebau, SK Plontke - Hearing Research, 2018 - Elsevier
Progress in drug delivery to the ear has been achieved over the last few years. This review
illustrates the main mechanisms of controlled drug release and the resulting geometry-and …

Comparison of electrode impedance measures between a dexamethasone-eluting and standard Cochlear™ Contour Advance® electrode in adult cochlear implant …

R Briggs, S O'Leary, C Birman, K Plant, R English… - Hearing Research, 2020 - Elsevier
Objective To compare the difference in electrode impedance across discrete time points to
24 months post-activation for two groups of adult cochlear implant recipients, one using an …

[HTML][HTML] Therapeutics for hearing preservation and improvement of patient outcomes in cochlear implantation—Progress and possibilities

RD Gay, YL Enke, JR Kirk, DR Goldman - Hearing Research, 2022 - Elsevier
The emergence of therapeutics targeted at hearing loss holds great promise in the
development of novel treatments for this heterogenous condition. Whilst such therapeutics …

Stem cell based drug delivery for protection of auditory neurons in a guinea pig model of cochlear implantation

V Scheper, A Hoffmann, MM Gepp, A Schulz… - Frontiers in Cellular …, 2019 - frontiersin.org
Background: The success of a cochlear implant (CI), which is the standard therapy for
patients suffering from severe to profound sensorineural hearing loss, depends on the …

Selective immunosuppression targeting the NLRP3 inflammasome mitigates the foreign body response to implanted biomaterials while preserving angiogenesis

AHP Chan, MJ Moore, AJ Grant… - Advanced …, 2023 - Wiley Online Library
Medical devices are a mainstay of the healthcare industry, providing clinicians with
innovative tools to diagnose, monitor, and treat a range of medical conditions. For …

Cochlear implantation with a dexamethasone eluting electrode array: functional and anatomical changes in non-human primates

R Manrique-Huarte, C Zulueta-Santos… - Otology & …, 2020 - journals.lww.com
Objectives: The aim of this study was to determine whether the dexamethasone-eluting
electrode (DEXEL) has a protective anti-inflammatory effect in a normal hearing implanted …

Intracochlear administration of steroids with a catheter during human cochlear implantation: a safety and feasibility study

NK Prenzler, R Salcher, M Timm, L Gaertner… - Drug delivery and …, 2018 - Springer
Suppression of foreign body reaction, improvement of electrode-nerve interaction, and
preservation of residual hearing are essential research topics in cochlear implantation …

Immune response after cochlear implantation

E Simoni, E Gentilin, M Candito, G Borile… - Frontiers in …, 2020 - frontiersin.org
A cochlear implant (CI) is an electronic device that enables hearing recovery in patients with
severe to profound hearing loss. Although CIs are a successful treatment for profound …