Pharmacokinetic principles in the inner ear: Influence of drug properties on intratympanic applications
AN Salt, SK Plontke - Hearing research, 2018 - Elsevier
Local drug delivery to the ear has gained wide clinical acceptance, with the choice of drug
and application protocol in humans largely empirically-derived. Here, we review the …
and application protocol in humans largely empirically-derived. Here, we review the …
Biocompatible materials in otorhinolaryngology and their antibacterial properties
J Spałek, P Ociepa, P Deptuła, E Piktel… - International Journal of …, 2022 - mdpi.com
For decades, biomaterials have been commonly used in medicine for the replacement of
human body tissue, precise drug-delivery systems, or as parts of medical devices that are …
human body tissue, precise drug-delivery systems, or as parts of medical devices that are …
Controlled drug release to the inner ear: Concepts, materials, mechanisms, and performance
Progress in drug delivery to the ear has been achieved over the last few years. This review
illustrates the main mechanisms of controlled drug release and the resulting geometry-and …
illustrates the main mechanisms of controlled drug release and the resulting geometry-and …
Comparison of electrode impedance measures between a dexamethasone-eluting and standard Cochlear™ Contour Advance® electrode in adult cochlear implant …
Objective To compare the difference in electrode impedance across discrete time points to
24 months post-activation for two groups of adult cochlear implant recipients, one using an …
24 months post-activation for two groups of adult cochlear implant recipients, one using an …
[HTML][HTML] Therapeutics for hearing preservation and improvement of patient outcomes in cochlear implantation—Progress and possibilities
RD Gay, YL Enke, JR Kirk, DR Goldman - Hearing Research, 2022 - Elsevier
The emergence of therapeutics targeted at hearing loss holds great promise in the
development of novel treatments for this heterogenous condition. Whilst such therapeutics …
development of novel treatments for this heterogenous condition. Whilst such therapeutics …
Stem cell based drug delivery for protection of auditory neurons in a guinea pig model of cochlear implantation
Background: The success of a cochlear implant (CI), which is the standard therapy for
patients suffering from severe to profound sensorineural hearing loss, depends on the …
patients suffering from severe to profound sensorineural hearing loss, depends on the …
Selective immunosuppression targeting the NLRP3 inflammasome mitigates the foreign body response to implanted biomaterials while preserving angiogenesis
Medical devices are a mainstay of the healthcare industry, providing clinicians with
innovative tools to diagnose, monitor, and treat a range of medical conditions. For …
innovative tools to diagnose, monitor, and treat a range of medical conditions. For …
Cochlear implantation with a dexamethasone eluting electrode array: functional and anatomical changes in non-human primates
R Manrique-Huarte, C Zulueta-Santos… - Otology & …, 2020 - journals.lww.com
Objectives: The aim of this study was to determine whether the dexamethasone-eluting
electrode (DEXEL) has a protective anti-inflammatory effect in a normal hearing implanted …
electrode (DEXEL) has a protective anti-inflammatory effect in a normal hearing implanted …
Intracochlear administration of steroids with a catheter during human cochlear implantation: a safety and feasibility study
NK Prenzler, R Salcher, M Timm, L Gaertner… - Drug delivery and …, 2018 - Springer
Suppression of foreign body reaction, improvement of electrode-nerve interaction, and
preservation of residual hearing are essential research topics in cochlear implantation …
preservation of residual hearing are essential research topics in cochlear implantation …
Immune response after cochlear implantation
E Simoni, E Gentilin, M Candito, G Borile… - Frontiers in …, 2020 - frontiersin.org
A cochlear implant (CI) is an electronic device that enables hearing recovery in patients with
severe to profound hearing loss. Although CIs are a successful treatment for profound …
severe to profound hearing loss. Although CIs are a successful treatment for profound …