Bacterial infections have attracted the attention of researchers in recent decades, especially
due to the special problems they have faced, such as their increasing diversity and …

Click chemistry has emerged as a valuable tool for rapid compound synthesis, presenting
notable advantages and convenience in the exploration of potential drug candidates. In …

Aim: A fragment-based design and synthesis of three novel series of aminopyridone-linked
benzimidazoles as potential anticancer candidates with significant CDK9 inhibition was …

Adopting the molecular overlay approach, three novel sets of thiazepinopurines with
expected cytotoxicity and CDK2 inhibition potential were designed and synthesized. This …

In this study, we present the highly efficient and rapid synthesis of substituted
dihydropyrimidinone derivatives through an ultrasound-accelerated approach. We utilize …

Aim: A novel series of fused benzochromenes with expected cytotoxicity and HIF-1α
inhibition was identified. Materials & methods: A bioisosterism-aided approach was applied …

With the aim to identify new antiviral agents with antibacterial properties, a series of 2-
quinolone-1, 2, 3-triazole derivatives bearing α-aminophosphonates was synthesized and …

A series of twelve azomethine analogs (3a-l) of 4-aminoantipyrine (4-AA) were prepared
and characterized using FT-IR, 1 HNMR and EI mass spectrometric analysis. Analog 3f was …

The development of nanomaterials has been speedily established in recent years, yet
nanoparticles synthesized by traditional methods suffer unacceptable toxicity and the …

Considering the promising effects of molecular hybridization on drug discovery in recent
years and the ongoing endeavors to develop bioactive scaffolds tethering the 1, 2, 3-triazole …