[HTML][HTML] Benzimidazole-triazole hybrids as antimicrobial and antiviral agents: A systematic review
M Marinescu - Antibiotics, 2023 - mdpi.com
Bacterial infections have attracted the attention of researchers in recent decades, especially
due to the special problems they have faced, such as their increasing diversity and …
due to the special problems they have faced, such as their increasing diversity and …
Click chemistry-aided drug discovery: A retrospective and prospective outlook
R Zhao, J Zhu, X Jiang, R Bai - European Journal of Medicinal Chemistry, 2023 - Elsevier
Click chemistry has emerged as a valuable tool for rapid compound synthesis, presenting
notable advantages and convenience in the exploration of potential drug candidates. In …
notable advantages and convenience in the exploration of potential drug candidates. In …
Aminopyridone-linked benzimidazoles: a fragment-based drug design for the development of CDK9 inhibitors
EM Husseiny, HS Abulkhair, SSA El-Hddad… - Future Medicinal …, 2023 - Taylor & Francis
Aim: A fragment-based design and synthesis of three novel series of aminopyridone-linked
benzimidazoles as potential anticancer candidates with significant CDK9 inhibition was …
benzimidazoles as potential anticancer candidates with significant CDK9 inhibition was …
Molecular overlay-guided design of new CDK2 inhibitor thiazepinopurines: Synthesis, anticancer, and mechanistic investigations
Adopting the molecular overlay approach, three novel sets of thiazepinopurines with
expected cytotoxicity and CDK2 inhibition potential were designed and synthesized. This …
expected cytotoxicity and CDK2 inhibition potential were designed and synthesized. This …
[HTML][HTML] CuFe2O4 Magnetic Nanoparticles as Heterogeneous Catalysts for Synthesis of Dihydropyrimidinones as Inhibitors of SARS-CoV-2 Surface Proteins …
In this study, we present the highly efficient and rapid synthesis of substituted
dihydropyrimidinone derivatives through an ultrasound-accelerated approach. We utilize …
dihydropyrimidinone derivatives through an ultrasound-accelerated approach. We utilize …
Novel benzochromenes: design, synthesis, cytotoxicity, molecular docking and mechanistic investigations
FG Abdulrahman, HS Abulkhair, RA Zidan… - Future Medicinal …, 2024 - Taylor & Francis
Aim: A novel series of fused benzochromenes with expected cytotoxicity and HIF-1α
inhibition was identified. Materials & methods: A bioisosterism-aided approach was applied …
inhibition was identified. Materials & methods: A bioisosterism-aided approach was applied …
Design, synthesis and molecular modeling studies of novel 2-quinolone-1, 2, 3-triazole-α-aminophosphonates hybrids as dual antiviral and antibacterial agents
K El Gadali, M Rafya, M Maatallah, A Vanderlee… - European Journal of …, 2024 - Elsevier
With the aim to identify new antiviral agents with antibacterial properties, a series of 2-
quinolone-1, 2, 3-triazole derivatives bearing α-aminophosphonates was synthesized and …
quinolone-1, 2, 3-triazole derivatives bearing α-aminophosphonates was synthesized and …
Synthesis, crystal structure, biological evaluation, in silico ADME properties, enzymatic target prediction and molecular docking studies of pyrazolone-azomethine …
A series of twelve azomethine analogs (3a-l) of 4-aminoantipyrine (4-AA) were prepared
and characterized using FT-IR, 1 HNMR and EI mass spectrometric analysis. Analog 3f was …
and characterized using FT-IR, 1 HNMR and EI mass spectrometric analysis. Analog 3f was …
[HTML][HTML] Introducing the antibacterial and photocatalytic degradation potentials of biosynthesized chitosan, chitosan–ZnO, and chitosan–ZnO/PVP nanoparticles
A Aouadi, D Hamada Saud, A Rebiai, A Achouri… - Scientific Reports, 2024 - nature.com
The development of nanomaterials has been speedily established in recent years, yet
nanoparticles synthesized by traditional methods suffer unacceptable toxicity and the …
nanoparticles synthesized by traditional methods suffer unacceptable toxicity and the …
Design and synthesis of chromene-1, 2, 3-triazole benzene sulfonamide hybrids as potent carbonic anhydrase-IX inhibitors against prostate cancer
FF Albelwi, MS Nafie, NR Albujuq, W Hourani… - RSC Medicinal …, 2024 - pubs.rsc.org
Considering the promising effects of molecular hybridization on drug discovery in recent
years and the ongoing endeavors to develop bioactive scaffolds tethering the 1, 2, 3-triazole …
years and the ongoing endeavors to develop bioactive scaffolds tethering the 1, 2, 3-triazole …