IgGs are essential soluble components of the adaptive immune response that evolved to
protect the body from infection. Compared with other immunoglobulins, the role of IgGs is …

Endocytosis is a complex process whereby cell surface proteins, lipids and fluid from the
extracellular environment are packaged, sorted and internalized into cells. Endocytosis is …

Antibodies are essential components of an adaptive immune response. Immunoglobulin G
(IgG) is the most common type of antibody found in circulation and extracellular fluids …

While cancer cell proliferation depends on access to extracellular nutrients, inadequate
tumour perfusion means that glucose, amino acids and lipids are often in short supply. To …

We improve the potency of antibody–drug conjugates (ADCs) containing the human
epidermal growth factor receptor 2 (HER2)-specific antibody pertuzumab by substantially …

As an essential modulator of IgG disposition, the neonatal Fc receptor (FcRn) governs the
pharmacokinetics and functions many therapeutic modalities. In this review, we thoroughly …

Introduction Respiratory diseases represent a worldwide health issue. The recent Sars-CoV-
2 pandemic, the burden of lung cancer, and inflammatory respiratory diseases urged the …

Pancreatic ductal adenocarcinoma (PDAC) is a dominantly (~ 95%) KRAS-mutant cancer
that has extremely poor prognosis, in part this is due to its strong intrinsic resistance towards …

There is an urgent need to identify new cellular targets to expand the repertoire, potency and
safety of cancer therapeutics. Neonatal Fc Receptor (FcRn)-driven cellular recycling plays a …

Albumin accumulation in tumours could reflect a role of albumin in transport of endogenous
nutrient cargos required for cellular growth and not just a suggested source of amino acids; …