[HTML][HTML] Derlin rhomboid pseudoproteases employ substrate engagement and lipid distortion to enable the retrotranslocation of ERAD membrane substrates
Nearly one-third of proteins are initially targeted to the endoplasmic reticulum (ER)
membrane, where they are correctly folded and then delivered to their final cellular …
membrane, where they are correctly folded and then delivered to their final cellular …
Yeast derlin Dfm1 employs a chaperone-like function to resolve misfolded membrane protein stress
Protein aggregates are a common feature of diseased and aged cells. Membrane proteins
comprise a quarter of the proteome, and yet, it is not well understood how aggregation of …
comprise a quarter of the proteome, and yet, it is not well understood how aggregation of …
An ERAD‐independent role for rhomboid pseudoprotease Dfm1 in mediating sphingolipid homeostasis
Nearly one‐third of nascent proteins are initially targeted to the endoplasmic reticulum (ER),
where they are correctly folded and assembled before being delivered to their final cellular …
where they are correctly folded and assembled before being delivered to their final cellular …
Derlin Dfm1 employs a chaperone function to resolve misfolded membrane protein stress
Accumulation of misfolded proteins is a known source of cellular stress and can be
detrimental to cellular health. While protein aggregation is a known hallmark of many …
detrimental to cellular health. While protein aggregation is a known hallmark of many …