Optical tissue clearing refers to physico-chemical treatments which make thick biological
samples transparent by removal of refractive index gradients and light absorbing …

Improvement of imaging quality has the potential to visualize previously unseen building
blocks of the brain and is therefore one of the great challenges in neuroscience. Rapid …

Sažetak Recent advances in microscopy have enabled cellular-resolution imaging of thick
tissue samples or even whole organs. The natural opacity of organs and tissues acts as a …

Background Although tissue clearing and subsequent whole-brain imaging is now possible,
standard protocols need to be adjusted to the innate properties of each specific tissue for …

Simultaneous visualisation of vasculature and surrounding tissue structures is essential for a
better understanding of vascular pathologies. In this work, we describe a histochemical …

Significance: To explore brain architecture and pathology, a consistent and reliable
methodology to visualize the three-dimensional cerebral microvasculature is beneficial …

Activation of adaptive immunity is a complex process coordinated at multiple levels in both
time and the three-dimensional context of reactive lymph nodes (LNs). Although microscopy …

Optical coherence tomography has become an indispensable diagnostic tool in
ophthalmology for imaging the retina and the anterior segment of the eye. However, the …

Recent advances in optical clearing techniques have dramatically improved deep tissue
imaging by reducing the obscuring effects of light scattering and absorption. However, these …

Cerebral microhemorrhages (CMHs) are associated with cerebrovascular disease, cognitive
impairment, and normal aging. One method to study CMHs is to analyze histological …