Globally, the number of people with multiple co-occurring diseases will increase
substantially over the coming decades, with important consequences for patients, carers …

Obesity is the most extended metabolic alteration worldwide increasing the risk for the
development of cardiometabolic alterations such as type 2 diabetes, hypertension, and …

Nanopore platform holds a great fascination that attracts increasing interests in research and
leads the development of various domains. Herein we first briefly introduce the …

Diet modulates the genetic risk of obesity, but the modulation has been rarely studied using
genetic risk scores (GRSs) in children. Our objectives were to identify single nucleotide …

Obesity is a major risk factor for many common diseases and has a substantial heritable
component. To identify new genetic determinants, we performed exome-sequence analyses …

Medicinal chemistry efforts typically focus on drug–protein interactions and overlook RNA
binding as a source of off-target pharmacology. Now, a new method has been developed to …

Background The influence of genetics and environment on the association of the plasma
proteome with body mass index (BMI) and changes in BMI remains underexplored, and the …

Using a unified method of the extended first-principles molecular dynamics, we report a wide-
range (density ρ= 2.329–18.632 g/cm 3, temperature T= 1.00× 10 4–1.29× 10 8 K) equation …

Genome-wide association studies (GWASs) have achieved remarkable success in
associating thousands of genetic variants with complex traits. However, the presence of …

In this study, we present a comprehensive investigation of positive leader discharges, with
the aim of enhancing our understanding of leader decay and reactivation. Our approach …