The term “circadian rhythms” describes endogenous oscillations with ca. 24-h period
associated with the earth's daily rotation and light/dark cycle. Such rhythms reflect the …

The circadian clock evolved in diverse organisms to integrate external environmental
changes and internal physiology. The clock endows the host with temporal precision and …

Ferroptosis is an outcome of metabolic disorders and closely linked to liver cancer.
However, the mechanism underlying the fine regulation of ferroptosis in liver cancer remains …

Pyruvate dehydrogenase kinase (PDK) can regulate the catalytic activity of pyruvate
decarboxylation oxidation via the mitochondrial pyruvate dehydrogenase complex, and it …

Rosacea is significantly associated with dementia, particularly Alzheimer's disease (AD).
However, the common underlying molecular mechanism connecting these two diseases …

In this overview, we provide an update on recent progress made in understanding the
mechanisms of action, physiological functions, and roles in disease of retinoic acid related …

Circadian timekeeping systems drive oscillatory gene expression to regulate essential
cellular and physiological processes. When the systems are perturbed, pathological …

Impaired glucose homeostasis is one of the risk factors for causing metabolic diseases
including obesity, type 2 diabetes, and cancers. In glucose metabolism, pyruvate …

Simple Summary The circadian timing system is our bodies' built-in clock and controls our
physiology on a daily basis. This system helps us adapt to changes in our environment, such …

Retinoic acid receptor-related orphan receptor-α (RORα) is a member of the orphan nuclear
receptor family and functions as a transcriptional activator in response to circadian changes …