Time-restricted eating (TRE) is a dietary intervention that limits food consumption to a
specific time window each day. The effect of TRE on body weight and physiological …

The finding that animals with circadian gene mutations exhibit diet-induced obesity and
metabolic syndrome with hypoinsulinemia revealed a distinct role for the clock in the brain …

Caloric restriction (CR) prolongs life span, yet the mechanisms by which it does so remain
poorly understood. Under CR, mice self-impose chronic cycles of 2-hour feeding and 22 …

Compositional oscillations of the gut microbiome are essential for normal peripheral
circadian rhythms, both of which are disrupted in diet-induced obesity (DIO). Although time …

Physical endurance and energy conservation are essential for survival in the wild. However,
it remains unknown whether and how meal timing regulates physical endurance and muscle …

Characteristics of the gut microbiome vary synchronously with changes in host diet.
However, the underlying effects of these fluctuations remain unclear. Here, we performed …

Patients admitted to the intensive care unit (ICU) are in need of continuous organ
replacement strategies and specialized care, for example because of neurological …

Physiology is regulated by interconnected cell and tissue circadian clocks. Disruption of the
rhythms generated by the concerted activity of these clocks is associated with metabolic …

A wide variety of liver functions are regulated daily by the liver circadian clock and via
systemic circadian control by other organs and cells within the gastrointestinal tract as well …

A thorough understanding of the mechanisms controlling energy homeostasis is needed to
prevent and treat metabolic morbidities. While the contribution of organs such as the liver …