Recent advance on carbamate-based cholinesterase inhibitors as potential multifunctional agents against Alzheimer's disease

H Zhang, Y Wang, Y Wang, X Li, S Wang… - European Journal of …, 2022 - Elsevier
Abstract Alzheimer's disease (AD), as the fourth leading cause of death among the elderly
worldwide, has brought enormous challenge to the society. Due to its extremely complex …

[HTML][HTML] The mechanism of microglia-mediated immune inflammation in ischemic stroke and the role of natural botanical components in regulating microglia: A review

J Zeng, T Bao, K Yang, X Zhu, S Wang… - Frontiers in …, 2023 - frontiersin.org
Ischemic stroke (IS) is one of the most fatal diseases. Neuroimmunity, inflammation, and
oxidative stress play important roles in various complex mechanisms of IS. In particular, the …

Clinical benefits and pharmacology of scutellarin: A comprehensive review

L Wang, Q Ma - Pharmacology & therapeutics, 2018 - Elsevier
Stroke and myocardial infarction are among the most common causes of mortality and
disability in the world. The ischemic injury underlying these illnesses is complex, involving …

Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998–2018)

P Mishra, A Kumar, G Panda - Bioorganic & Medicinal Chemistry, 2019 - Elsevier
Alzheimer's disease (AD) is a genetically complex, progressive and irreversible
neurodegenerative disorder of the brain which involves multiple associated etiological …

Therapeutic potential of naringin in neurological disorders

S Ahmed, H Khan, M Aschner, MM Hasan… - Food and chemical …, 2019 - Elsevier
Neurological illnesses are multifactorial incurable debilitating disorders that may cause
neurodegeneration. These diseases influence approximately 30 million people around the …

[HTML][HTML] Avicenna's Canon of Medicine: a review of analgesics and anti-inflammatory substances

S Mahdizadeh, MK Ghadiri, A Gorji - Avicenna journal of …, 2015 - ncbi.nlm.nih.gov
Naturally occurring substances mentioned in medieval medical literatures currently have,
and will continue to have, a crucial place in drug discovery. Avicenna was a Persian …

Multifunctional scutellarin–rivastigmine hybrids with cholinergic, antioxidant, biometal chelating and neuroprotective properties for the treatment of Alzheimer's disease

Z Sang, Y Li, X Qiang, G Xiao, Q Liu, Z Tan… - Bioorganic & Medicinal …, 2015 - Elsevier
To discover multifunctional agents for the treatment of Alzheimer's disease (AD), a series of
scutellarein carbamate derivatives were designed and synthesized based on the multitarget …

Recent advances in the development of neuroprotective agents and therapeutic targets in the treatment of cerebral ischemia

Y Luo, H Tang, H Li, R Zhao, Q Huang, J Liu - European journal of …, 2019 - Elsevier
Stroke is a central nervous system disease that seriously affects people's quality of life and
has the second highest rate of morbidity and mortality in the world. At present, clinical …

Therapeutic potentials of crocin in medication of neurological disorders

S Ahmed, MM Hasan, M Heydari, A Rauf… - Food and Chemical …, 2020 - Elsevier
Neurological sicknesses are serious, multifactorial, debilitating disorders that may cause
neurodegeneration. Neuroprotection is the protection of the structure and capacity of …

[HTML][HTML] Comprehensive review on the interaction between natural compounds and brain receptors: Benefits and toxicity

AR Silva, C Grosso, C Delerue-Matos… - European journal of …, 2019 - Elsevier
Given their therapeutic activity, natural products have been used in traditional medicines
throughout the centuries. The growing interest of the scientific community in …