The leucine-rich repeat kinase 2 (LRRK2) gene and α-synuclein gene (SNCA) are the key
influencing factors of Parkinson's disease (PD). It is reported that dysfunction of LRRK2 may …

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the
loss of dopaminergic neurons in the substantia nigra pars compacta, leading to motor …

Background The immune system is a promising therapeutic target for disease modification in
Parkinson's disease (PD), but appropriate immune‐related biomarkers must be identified to …

Objectives Inflammatory bowel disease (IBD) is a chronic inflammatory disorder. Previous
studies have suggested that chronic systemic inflammation increases the risk of Parkinson's …

Mutations in the leucine‐rich repeat kinase 2 (LRRK2) are associated with Parkinson's
disease, chronic inflammation and mycobacterial infections. Although there is evidence …

The proteins alpha-synuclein (αSyn) and leucine rich repeat kinase 2 (LRRK2) are both key
players in the pathogenesis of the neurodegenerative disorder Parkinson's disease (PD) …

Rab proteins compose the largest family of small GTPases and control the different steps of
intracellular membrane traffic. More recently, they have been shown to also regulate cell …

Aims The leucine‐rich repeat kinase 2 (LRRK 2) G2019S mutation is the most common
genetic cause of Parkinson's disease (PD). There is compelling evidence that PD is not only …

Leucine-rich repeat kinase 2 (LRRK2) is a common gene implicated in Parkinson's disease
and many inflammatory processes. Thus, we assessed the role of LRRK2 in the context of …

Genetic evidence links mutations in the LRRK2 gene with an increased risk of Parkinson's
disease, for which no neuroprotective or neurorestorative therapies currently exist. While the …