Understanding the language of Lys36 methylation at histone H3
EJ Wagner, PB Carpenter - Nature reviews Molecular cell biology, 2012 - nature.com
Histone side chains are post-translationally modified at multiple sites, including at Lys36 on
histone H3 (H3K36). Several enzymes from yeast and humans, including the …
histone H3 (H3K36). Several enzymes from yeast and humans, including the …
Endocrine resistance in hormone receptor positive breast cancer–from mechanism to therapy
A Rani, J Stebbing, G Giamas, J Murphy - Frontiers in endocrinology, 2019 - frontiersin.org
The importance and role of the estrogen receptor (ER) pathway has been well-documented
in both breast cancer (BC) development and progression. The treatment of choice in women …
in both breast cancer (BC) development and progression. The treatment of choice in women …
The NF1 somatic mutational landscape in sporadic human cancers
C Philpott, H Tovell, IM Frayling, DN Cooper… - Human genomics, 2017 - Springer
Abstract Background Neurofibromatosis type 1 (NF1: Online Mendelian Inheritance in Man
(OMIM)# 162200) is an autosomal dominantly inherited tumour predisposition syndrome …
(OMIM)# 162200) is an autosomal dominantly inherited tumour predisposition syndrome …
Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions
Identification of effective combination therapies is critical to address the emergence of drug-
resistant cancers, but direct screening of all possible drug combinations is infeasible. Here …
resistant cancers, but direct screening of all possible drug combinations is infeasible. Here …
Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity
I Bajrami, JR Frankum, A Konde, RE Miller, FL Rehman… - Cancer research, 2014 - AACR
Small-molecule inhibitors of PARP1/2, such as olaparib, have been proposed to serve as a
synthetic lethal therapy for cancers that harbor BRCA1 or BRCA2 mutations. Indeed, in …
synthetic lethal therapy for cancers that harbor BRCA1 or BRCA2 mutations. Indeed, in …
Essential gene profiles in breast, pancreatic, and ovarian cancer cells
Genomic analyses are yielding a host of new information on the multiple genetic
abnormalities associated with specific types of cancer. A comprehensive description of …
abnormalities associated with specific types of cancer. A comprehensive description of …
Tumours associated with BAP1 mutations
Summary BAP1 (BRCA1-Associated Protein 1) was initially identified as a protein that binds
to BRCA1. BAP1 is a tumour suppressor that is believed to mediate its effects through …
to BRCA1. BAP1 is a tumour suppressor that is believed to mediate its effects through …
Inactivating NF1 Mutations Are Enriched in Advanced Breast Cancer and Contribute to Endocrine Therapy Resistance
A Pearson, P Proszek, J Pascual, C Fribbens… - Clinical Cancer …, 2020 - AACR
Purpose: Advanced breast cancer (ABC) has not been subjected to the same degree of
molecular scrutiny as early primary cancer. Breast cancer evolves with time and under the …
molecular scrutiny as early primary cancer. Breast cancer evolves with time and under the …
Acquired FGFR and FGF Alterations Confer Resistance to Estrogen Receptor (ER) Targeted Therapy in ER+ Metastatic Breast Cancer
Purpose: To identify clinically relevant mechanisms of resistance to ER-directed therapies in
ER+ breast cancer. Experimental Design: We conducted a genome-scale functional screen …
ER+ breast cancer. Experimental Design: We conducted a genome-scale functional screen …