Interferons α and β in cancer: therapeutic opportunities from new insights

EC Borden - Nature Reviews Drug Discovery, 2019 - nature.com
Over the past decade, preclinical and clinical research have confirmed the essential role of
interferons for effective host immunological responses to malignant cells. Type I interferons …

Cancer spheroids and organoids as novel tools for research and therapy: state of the art and challenges to guide precision medicine

S El Harane, B Zidi, N El Harane, KH Krause, T Matthes… - Cells, 2023 - mdpi.com
Spheroids and organoids are important novel players in medical and life science research.
They are gradually replacing two-dimensional (2D) cell cultures. Indeed, three-dimensional …

Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B

M Musella, A Guarracino, N Manduca, C Galassi… - Nature …, 2022 - nature.com
Cancer stem cells (CSCs) are a subpopulation of cancer cells endowed with high
tumorigenic, chemoresistant and metastatic potential. Nongenetic mechanisms of acquired …

Lenvatinib plus anti-PD-1 antibody combination treatment activates CD8+ T cells through reduction of tumor-associated macrophage and activation of the interferon …

YU Kato, K Tabata, T Kimura, A Yachie-Kinoshita… - PloS one, 2019 - journals.plos.org
Lenvatinib is a multiple receptor tyrosine kinase inhibitor targeting mainly vascular
endothelial growth factor (VEGF) and fibroblast growth factor (FGF) receptors. We …

Microfluidic modelling of the tumor microenvironment for anti-cancer drug development

M Shang, RH Soon, CT Lim, BL Khoo, J Han - Lab on a Chip, 2019 - pubs.rsc.org
Cancer is the leading cause of death worldwide. The complex and disorganized tumor
microenvironment makes it very difficult to treat this disease. The most common in vitro drug …

Classification of M1/M2-polarized human macrophages by label-free hyperspectral reflectance confocal microscopy and multivariate analysis

FR Bertani, P Mozetic, M Fioramonti, M Iuliani… - Scientific reports, 2017 - nature.com
The possibility of detecting and classifying living cells in a label-free and non-invasive
manner holds significant theranostic potential. In this work, Hyperspectral Imaging (HSI) has …

Immunotherapy discovery on tumor organoid-on-a-chip platforms that recapitulate the tumor microenvironment

J Zhang, H Tavakoli, L Ma, X Li, L Han, XJ Li - Advanced drug delivery …, 2022 - Elsevier
Cancer immunotherapy has achieved remarkable success over the past decade by
modulating patients' own immune systems and unleashing pre-existing immunity. However …

[HTML][HTML] Epigenetics and immunotherapy: the current state of play

J Dunn, S Rao - Molecular immunology, 2017 - Elsevier
Cancer cells employ a number of mechanisms to escape immunosurveillance and facilitate
tumour progression. The recent explosion of interest in immunotherapy, especially immune …

Immunomodulation by ionizing radiation—impact for design of radio‐immunotherapies and for treatment of inflammatory diseases

B Frey, M Rückert, L Deloch, PF Rühle… - Immunological …, 2017 - Wiley Online Library
Ionizing radiation is often regarded as an element of danger. But, danger responses on the
cellular and molecular level are often beneficial with regard to the induction of anti‐tumor …

Dissecting effects of anti-cancer drugs and cancer-associated fibroblasts by on-chip reconstitution of immunocompetent tumor microenvironments

M Nguyen, A De Ninno, A Mencattini, F Mermet-Meillon… - Cell reports, 2018 - cell.com
A major challenge in cancer research is the complexity of the tumor microenvironment,
which includes the host immunological setting. Inspired by the emerging technology of …