99% of administered nanoparticles will accumulate and sequester in the liver after
administration into the body. This results in reduced delivery to the targeted diseased tissue …

The present review sets out to discuss recent developments of the effects and mechanisms
of carrier properties on their circulation time. For most drugs, sufficient in vivo circulation time …

A meta‐analysis was performed to assess and compare the accuracies of magnetic
resonance elastography (MRE) and diffusion‐weighted imaging (DWI) for the staging of …

Molecular imaging holds the potential for noninvasive and accurate grading of liver fibrosis.
It is limited by the lack of biomarkers that strongly correlate with liver fibrosis grade. Here, we …

The poor access of therapeutic drugs and genetic material into the central nervous system
due to the presence of the blood–brain barrier often limits the development of effective …

Purpose: To characterize longitudinal changes in molecular water diffusion, blood
microcirculation, and their contributions to the apparent diffusion changes using intravoxel …

Following injurious stimuli, quiescent hepatic stellate cells (qHSCs) transdifferentiate into
activated HSCs (aHSCs). aHSCs play pivotal roles in the onset and progression of liver …

The response to injury is one of wound healing and fibrogenesis, which ultimately leads to
fibrosis. The fibrogenic response to injury is a generalized one across virtually all organ …

Fibrosis, or the accumulation of extracellular matrix molecules that make up scar tissue, is a
common result of chronic tissue injury. Advances in the clinical management of fibrotic …

Aims Chronic liver disease (CLD) is a serious medical condition affecting patients globally
and pain management poses a unique challenge. ATP-sensitive potassium channels (K …