The mammalian heart is a highly specialized organ, comprised of many different cell types
arising from distinct embryonic progenitor populations during cardiogenesis. Three …

The formation of the heart is a complex morphogenetic process that depends on the
spatiotemporally regulated contribution of cardiac progenitor cells. These mainly derive from …

This review discusses the function of neural crest as they relate to cardiovascular defects.
The cardiac neural crest cells are a subpopulation of cranial neural crest discovered nearly …

The myocardium of the heart is composed of multiple highly specialized myocardial
lineages, including those of the ventricular and atrial myocardium, and the specialized …

Although de la Cruz and colleagues showed as early as 1977 that the outflow tract was
added after the heart tube formed, the source of these secondarily added cells was not …

Insight into the mechanisms underlying congenital heart defects and the use of stem cells for
cardiac repair are major research goals in cardiovascular biology. In the early embryo …

Publisher Summary This chapter discusses the findings that preceded and led to the
identification of this progenitor cell population, and different molecular and genetic …

Neural crest cells are multipotential cells that delaminate from the dorsal neural tube and
migrate widely throughout the body. A subregion of the cranial neural crest originating …

Recent studies have demonstrated that the LIM homeodomain transcription factor Islet1
(Isl1) marks pluripotent cardiovascular progenitor cells and is required for proliferation …

Retinoic acid (RA), the active derivative of vitamin A, has been implicated in various steps of
cardiovascular development. The retinaldehyde dehydrogenase 2 (RALDH2) enzyme …