Aberrant chromosomal architecture, ranging from small insertions or deletions to large
chromosomal alterations, is one of the most common characteristics of cancer genomes …

Mitotic cell division is tightly monitored by checkpoints that safeguard the genome from
instability. Failures in accurate chromosome segregation during mitosis can cause …

Chromosomal instability (CIN) drives cancer cell evolution, metastasis and therapy
resistance, and is associated with poor prognosis. CIN leads to micronuclei that release …

Mitotic errors lead to aneuploidy, a condition of karyotype imbalance, frequently found in
cancer cells. Alterations in chromosome copy number induce a wide variety of cellular …

Aneuploidy is a ubiquitous feature of human tumors, but the acquisition of aneuploidy
typically antagonizes cellular fitness. To investigate how aneuploidy could contribute to …

Chromosomal instability (CIN) and epigenetic alterations have been implicated in tumor
progression and metastasis; yet how these two hallmarks of cancer are related remains …

High levels of aneuploidy and chromosomal instability (CIN) are correlated with poor patient
outcomes, though the mechanism (s) underlying this relationship have not been established …

Chromosomal instability (CIN) is a hallmark of tumor cells caused by changes in the
dynamics and control of microtubules that compromise the mitotic spindle. Thus, CIN cells …

Cancer cells often display chromosomal instability (CIN), a defect that involves loss or
rearrangement of the cell's genetic material–chromosomes–during cell division. This …

Chromosomal instability (CIN) is a hallmark of cancer and is associated with tumor cell
malignancy. CIN triggers a chain reaction in cells leading to chromosomal abnormalities …