The complexes of the electron transport chain and ATP synthase comprise the oxidative
phosphorylation (OXPHOS) system. The reactions of OXPHOS generate the mitochondrial …

The major role of mitochondria is to provide cells with energy, but no less important are their
roles in responding to various stress factors and the metabolic changes and pathological …

Protein O-GlcNAcylation is increasingly recognized as an important cellular regulatory
mechanism, in multiple organs including the heart. However, the mechanisms leading to O …

In many tissues, stem cell (SC) proliferation is dynamically adjusted to regenerative needs.
How SCs adapt their metabolism to meet the demands of proliferation and how changes in …

The endogenous inhibitor of mitochondrial F 1 F o-ATPase (ATP synthase), IF 1, has been
shown to exert pro-oncogenic actions, including reprogramming of cellular energy …

Hypoxia is common in marine environments and a major stressor for marine organisms
inhabiting benthic and intertidal zones. Several studies have explored the responses of …

Parkinson's disease (PD) is a major cause of morbidity and mortality among older
individuals. Several researchers have suggested that iron chelators which cross the blood …

Traumatic brain injury (TBI) causes significant neurological deficits and long‐term
degenerative changes. Primary injury in TBI entails distinct neuroanatomical zones, ie …

Background The main drawback of BRAF/MEK inhibitors (BRAF/MEKi)-based targeted
therapy in the management of BRAF-mutated cutaneous metastatic melanoma (MM) is the …

Fluctuations in the ambient oxygen concentrations represent a major stressor for aerobic
organisms causing ATP deficiency during hypoxia and excessive production of reactive …