The biomechanics of induction in adolescent idiopathic scoliosis: theoretical factors

JF Sarwark, RM Castelein, A Maqsood, CE Aubin - JBJS, 2019 - journals.lww.com
Adolescent idiopathic scoliosis (AIS) is a common clinical condition that develops around
puberty, has implications for the rest of oneLs life, and is a classic enigma in orthopaedics …

Role of primary cilia in skeletal disorders

X Li, S Guo, Y Su, J Lu, D Hang, S Cao… - Stem cells …, 2022 - Wiley Online Library
Primary cilia are highly conserved microtubule‐based organelles that project from the cell
surface into the extracellular environment and play important roles in mechanosensation …

Ependymal polarity defects coupled with disorganized ciliary beating drive abnormal cerebrospinal fluid flow and spine curvature in zebrafish

H Xie, Y Kang, J Liu, M Huang, Z Dai, J Shi, S Wang… - Plos …, 2023 - journals.plos.org
Idiopathic scoliosis (IS) is the most common spinal deformity diagnosed in childhood or early
adolescence, while the underlying pathogenesis of this serious condition remains largely …

Idiopathic scoliosis as a rotatory decompensation of the spine

RM Castelein, S Pasha, JCY Cheng… - Journal of Bone and …, 2020 - academic.oup.com
Many years of dedicated research into the etiology of idiopathic scoliosis have not led to one
unified theory. We propose that scoliosis is a mechanical, rotatory decompensation of the …

Growth and nutritional status, and their association with lung function: a study from the international Primary Ciliary Dyskinesia Cohort

M Goutaki, FS Halbeisen, BD Spycher… - European …, 2017 - Eur Respiratory Soc
Chronic respiratory disease can affect growth and nutrition, which can influence lung
function. We investigated height, body mass index (BMI), and lung function in patients with …

Why, when and how to investigate primary ciliary dyskinesia in adult patients with bronchiectasis

M Contarini, A Shoemark, J Rademacher… - Multidisciplinary …, 2018 - Springer
Bronchiectasis represents the final pathway of several infectious, genetic, immunologic or
allergic disorders. Accurate and prompt identification of the underlying cause is a key …

[HTML][HTML] The axonemal dynein heavy chain 10 gene is essential for monocilia motility and spine alignment in zebrafish

Y Wang, BR Troutwine, H Zhang, RS Gray - Developmental biology, 2022 - Elsevier
Adolescent idiopathic scoliosis (AIS) is a common pediatric musculoskeletal disorder
worldwide, characterized by atypical spine curvatures in otherwise healthy children. Human …

Identification of Two Novel DNAAF2 Variants in Two Consanguineous Families with Primary Ciliary Dyskinesia

C Lu, D Yang, C Lei, R Wang, T Guo… - Pharmacogenomics and …, 2021 - Taylor & Francis
Background Dynein axonemal assembly factor 2 (DNAAF2) is involved in the early
preassembly of dynein in the cytoplasm, which is essential for motile cilia function. Primary …

Idiopathic scoliosis families highlight actin-based and microtubule-based cellular projections and extracellular matrix in disease etiology

EE Baschal, EA Terhune, CI Wethey… - G3: Genes …, 2018 - academic.oup.com
Idiopathic scoliosis (IS) is a structural lateral spinal curvature of≥ 10° that affects up to 3% of
otherwise healthy children and can lead to life-long problems in severe cases. It is well …

[HTML][HTML] Aetiological process of idiopathic scoliosis: From a normal growing spine into a complex 3D spinal deformity

TPC Schlösser, AI Tsirikos, RM Castelein - Orthopaedics and Trauma, 2021 - Elsevier
In more than a century of dedicated research into its aetio-pathogenesis, many attempts
have been made to understand the exact cause of idiopathic scoliosis. In the literature, the …