Epidermal growth factor receptor: mechanisms of activation and signalling
RN Jorissen, F Walker, N Pouliot, TPJ Garrett… - The EGF receptor …, 2003 - Elsevier
Publisher Summary This chapter discusses the structure and function of the epidermal
growth factor (EGF) receptor (EGFR), from ligand binding to the initiation of intracellular …
growth factor (EGF) receptor (EGFR), from ligand binding to the initiation of intracellular …
Alternative poly (A) site selection in complex transcription units: means to an end?
G Edwalds-Gilbert, KL Veraldi… - Nucleic acids …, 1997 - academic.oup.com
Many genes have been described and characterized which result in alternative
polyadenylation site use at the 3′-end of their mRNAs based on the cellular environment …
polyadenylation site use at the 3′-end of their mRNAs based on the cellular environment …
EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy
J Lupberger, MB Zeisel, F Xiao, C Thumann, I Fofana… - Nature medicine, 2011 - nature.com
Hepatitis C virus (HCV) is a major cause of liver disease, but therapeutic options are limited
and there are no prevention strategies. Viral entry is the first step of infection and requires …
and there are no prevention strategies. Viral entry is the first step of infection and requires …
[HTML][HTML] EGFR inhibition blocks cancer stem cell clustering and lung metastasis of triple negative breast cancer
X Liu, V Adorno-Cruz, YF Chang, Y Jia… - Theranostics, 2021 - ncbi.nlm.nih.gov
Triple-negative breast cancer (TNBC) is one of the most aggressive and metastatic breast
cancer subtypes lacking targeted therapy. Our recent work demonstrated that circulating …
cancer subtypes lacking targeted therapy. Our recent work demonstrated that circulating …
Integrated analysis of gene expression and copy number identified potential cancer driver genes with amplification-dependent overexpression in 1,454 solid tumors
K Ohshima, K Hatakeyama, T Nagashima… - Scientific reports, 2017 - nature.com
Identification of driver genes contributes to the understanding of cancer etiology and is
imperative for the development of individualized therapies. Gene amplification is a major …
imperative for the development of individualized therapies. Gene amplification is a major …
Cutaneous side effects of epidermal growth factor receptor inhibitors: clinical presentation, pathogenesis, and management
JC Hu, P Sadeghi, LC Pinter-Brown, S Yashar… - Journal of the American …, 2007 - Elsevier
The growing investigation and use of epidermal growth factor receptor (EGFR) inhibitors in
anticancer therapy has been motivated by their specificity for EGFR, which improves their …
anticancer therapy has been motivated by their specificity for EGFR, which improves their …
A novel juxtamembrane domain isoform of HER4/ErbB4: isoform-specific tissue distribution and differential processing in response to phorbol ester
Human epidermal growth factor receptor 4 (HER4) is a member of the epidermal growth
factor (EGF) receptor subfamily of receptor tyrosine kinases that is activated by neuregulins …
factor (EGF) receptor subfamily of receptor tyrosine kinases that is activated by neuregulins …
Clinical implications of the ErbB/epidermal growth factor (EGF) receptor family and its ligands in ovarian cancer
JM Lafky, JA Wilken, AT Baron, NJ Maihle - Biochimica et Biophysica Acta …, 2008 - Elsevier
The ERBB or EGF receptor (EGFR) proto-oncogene family, which consists of four structurally-
related transmembrane receptors (ie, EGFR, ErbB2, ErbB3, and ErbB4), plays an etiological …
related transmembrane receptors (ie, EGFR, ErbB2, ErbB3, and ErbB4), plays an etiological …
Comparative genomic sequence analysis and isolation of human and mouse alternative EGFR transcripts encoding truncated receptor isoforms
JL Reiter, DW Threadgill, GD Eley, KE Strunk… - Genomics, 2001 - Elsevier
This study presents the annotated genomic sequence and exon–intron organization of the
human and mouse epidermal growth factor receptor (EGFR) genes located on …
human and mouse epidermal growth factor receptor (EGFR) genes located on …
Epidermal growth factor receptor (EGFR)–related protein inhibits multiple members of the EGFR family in colon and breast cancer cells
H Xu, Y Yu, D Marciniak, AK Rishi, FH Sarkar… - Molecular cancer …, 2005 - AACR
Inactivation of epidermal growth factor receptor (EGFR) family members represents a
promising strategy for the development of selective therapies against epithelial cancers …
promising strategy for the development of selective therapies against epithelial cancers …