[HTML][HTML] Principles of RNA methylation and their implications for biology and medicine

Y Zhou, Y Kong, W Fan, T Tao, Q Xiao, N Li… - Biomedicine & …, 2020 - Elsevier
RNA methylation is a post-transcriptional level of regulation. At present, more than 150 kinds
of RNA modifications have been identified. They are widely distributed in messenger RNA …

Signaling pathways in the regulation of cancer stem cells and associated targeted therapy

W Manni, W Min - MedComm, 2022 - Wiley Online Library
Cancer stem cells (CSCs) are defined as a subpopulation of malignant tumor cells with
selective capacities for tumor initiation, self‐renewal, metastasis, and unlimited growth into …

N6-methyladenosine modification of ITGA6 mRNA promotes the development and progression of bladder cancer

H Jin, X Ying, B Que, X Wang, Y Chao, H Zhang… - …, 2019 - thelancet.com
Background Accumulating evidence has revealed the critical roles of N 6-methyladenosine
(m 6 A) modification of mRNA in various cancers. However, the biological function and …

[HTML][HTML] Targeted m6A demethylation of ITGA6 mRNA by a multisite dCasRx–m6A editor inhibits bladder cancer development

X Ying, Y Huang, B Liu, WY Hu, D Ji, C Chen… - Journal of Advanced …, 2024 - Elsevier
Abstract Introduction N6-methyladenosine (m 6 A) modification contributes to the
pathogenesis and development of various cancers, including bladder cancer (BCa). In …

[HTML][HTML] Notch signalling in cervical cancer

C Rodrigues, LR Joy, SP Sachithanandan… - Experimental cell …, 2019 - Elsevier
The initial discovery of key developmental signalling pathways, largely using classical
genetic approaches in model organisms, was followed by an intense burst of …

Cervical cancer stem cell‑associated genes: Prognostic implications in cervical cancer

J Organista‑Nava, Y Gómez‑Gómez… - Oncology …, 2019 - spandidos-publications.com
Cervical cancer is the fourth most common type of gynecological malignancy to affect
females, worldwide. Although high‑risk human papillomavirus (HR‑HPV) infection is the …

Reporters of cancer stem cells as a tool for drug discovery

A Mohan, R Raj R, G Mohan, P KP… - Frontiers in …, 2021 - frontiersin.org
In view of the importance of cancer stem cells (CSCs) in chemoresistance, metastasis and
recurrence, the biology of CSCs were explored in detail. Based on that, several modalities …

Markers and reporters to reveal the hierarchy in heterogeneous cancer stem cells

A Mohan, R Raj Rajan, G Mohan… - Frontiers in cell and …, 2021 - frontiersin.org
A subpopulation within cancer, known as cancer stem cells (CSCs), regulates tumor
initiation, chemoresistance, and metastasis. At a closer look, CSCs show functional …

[PDF][PDF] SF1: a standardised fraction of Clinacanthus nutans that inhibits the Stemness properties of Cancer Stem-Like cells derived from Cervical Cancer

F Ismail, Y Zakaria, MLM Isa, NFN Hassan - Sains Malaysiana, 2024 - irep.iium.edu.my
Cancer stem cells (CSCs) are a small population of tumour cells that are responsible for
tumour initiation, metastases, recurrence, and resistance to conventional therapy. Hence …

Integrin α6 (CD49f), the microenvironment and cancer stem cells

GD Bigoni-Ordóñez, D Czarnowski… - Current stem cell …, 2019 - ingentaconnect.com
Cancer is a highly prevalent and potentially terminal disease that affects millions of
individuals worldwide. Here, we review the literature exploring the intricacies of stem cells …