[HTML][HTML] GLP-1 receptor agonists: beyond their pancreatic effects

X Zhao, M Wang, Z Wen, Z Lu, L Cui, C Fu… - Frontiers in …, 2021 - frontiersin.org
Glucagon like peptide-1 (GLP-1) is an incretin secretory molecule. GLP-1 receptor agonists
(GLP-1RAs) are widely used in the treatment of type 2 diabetes (T2DM) due to their …

Cardiovascular safety and benefits of semaglutide in patients with type 2 diabetes: findings from SUSTAIN 6 and PIONEER 6

MA Nauck, DR Quast - Frontiers in endocrinology, 2021 - frontiersin.org
To exclude an excess risk of cardiovascular (CV) events, CV outcomes trials (CVOTs) have
assessed the effects of new glucose-lowering therapies, including glucagon-like peptide-1 …

Dipeptidyl peptidase‐4 inhibitors, glucagon‐like peptide 1 receptor agonists and sodium‐glucose co‐transporter‐2 inhibitors for people with cardiovascular disease: a …

Y Takaoka, T Suzuki, D Yoneoka… - Cochrane Database …, 2021 - cochranelibrary.com
Background Cardiovascular disease (CVD) is a leading cause of death globally. Recently,
dipeptidyl peptidase‐4 inhibitors (DPP4i), glucagon‐like peptide‐1 receptor agonists (GLP …

Bridging the gap between GLP1-receptor agonists and cardiovascular outcomes: evidence for the role of tirzepatide

F Taktaz, RA Fontanella, L Scisciola… - Cardiovascular …, 2024 - Springer
Tirzepatide is a new drug targeting glucagon-like peptide 1 (GLP1) and gastric inhibitory
polypeptide (GIP) receptors. This drug has demonstrated great potential in improving the …

Effect of icosapent ethyl on progression of coronary atherosclerosis in patients with elevated triglycerides on statin therapy: a prospective, placebo-controlled …

MJ Budoff, JB Muhlestein, DL Bhatt… - Cardiovascular …, 2021 - academic.oup.com
Aims Though statin therapy is known to slow coronary atherosclerosis progression and
reduce cardiovascular (CV) events, significant CV risk still remains. In the REDUCE-IT study …

[HTML][HTML] Cardiovascular protective properties of GLP-1 receptor agonists: more than just diabetic and weight loss drugs

R Le, MT Nguyen, MA Allahwala, JP Psaltis… - Journal of Clinical …, 2024 - mdpi.com
Owing to their potent glucose-lowering efficacy and substantial weight loss effects, glucagon-
like peptide-1 receptor agonists (GLP-1 RAs) are now considered part of the frontline …

Anti-inflammatory effects of sodium-glucose co-transporter 2 inhibitors on atherosclerosis

Y Kang, F Zhan, M He, Z Liu, X Song - Vascular Pharmacology, 2020 - Elsevier
Atherosclerosis is a very common macrovascular complication in type 2 diabetes mellitus,
and cardiovascular disease is the primary cause of death in diabetes patients. Sodium …

Incretin‐based therapies for the management of cardiometabolic disease in the clinic: Past, present, and future

JP Psaltis, JA Marathe, MT Nguyen… - Medicinal Research …, 2024 - Wiley Online Library
Among newer classes of drugs for type 2 diabetes mellitus (T2DM), glucagon‐like peptide 1
receptor agonists (GLP‐1 RAs) are incretin‐based agents that lower both blood sugar levels …

GLP-1 receptor agonists and coronary arteries: from mechanisms to events

A Pahud de Mortanges, E Sinaci… - Frontiers in …, 2022 - frontiersin.org
Objective: Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) lower plasma glucose
through effects on insulin and glucagon secretion and by decelerating gastric emptying. GLP …

Effect of oral semaglutide on cardiovascular parameters and their mechanisms in patients with type 2 diabetes: Rationale and design of the Semaglutide Anti …

M Janić, M Rizzo, F Cosentino, A Pantea Stoian… - Diabetes Therapy, 2022 - Springer
Abstract Introduction Type 2 diabetes (T2D) management has reached a point where not
only optimal glycaemic control is necessary, but also additional interventions with proven …