Multi-omics approaches to define calcific aortic valve disease pathogenesis
Calcific aortic valve disease sits at the confluence of multiple world-wide epidemics of aging,
obesity, diabetes, and renal dysfunction, and its prevalence is expected to nearly triple over …
obesity, diabetes, and renal dysfunction, and its prevalence is expected to nearly triple over …
Emerging role of long non-coding RNAs in diabetic vascular complications
VS Tanwar, MA Reddy, R Natarajan - Frontiers in endocrinology, 2021 - frontiersin.org
Chronic metabolic disorders such as obesity and diabetes are associated with accelerated
rates of macrovascular and microvascular complications, which are leading causes of …
rates of macrovascular and microvascular complications, which are leading causes of …
Single-nucleus chromatin accessibility profiling highlights regulatory mechanisms of coronary artery disease risk
Coronary artery disease (CAD) is a complex inflammatory disease involving genetic
influences across cell types. Genome-wide association studies have identified over 200 loci …
influences across cell types. Genome-wide association studies have identified over 200 loci …
ZEB2 Shapes the Epigenetic Landscape of Atherosclerosis
Background: Smooth muscle cells (SMCs) transition into a number of different phenotypes
during atherosclerosis, including those that resemble fibroblasts and chondrocytes, and …
during atherosclerosis, including those that resemble fibroblasts and chondrocytes, and …
Transcription factor regulation of eQTL activity across individuals and tissues
Tens of thousands of genetic variants associated with gene expression (cis-eQTLs) have
been discovered in the human population. These eQTLs are active in various tissues and …
been discovered in the human population. These eQTLs are active in various tissues and …
COLOCdb: a comprehensive resource for multi-model colocalization of complex traits
Large-scale genome-wide association studies (GWAS) have provided profound insights into
complex traits and diseases. Yet, deciphering the fine-scale molecular mechanisms of how …
complex traits and diseases. Yet, deciphering the fine-scale molecular mechanisms of how …
Comorbidity genetic risk and pathways impact SARS-CoV-2 infection outcomes
Understanding the genetic risk and mechanisms through which SARS-CoV-2 infection
outcomes and comorbidities interact to impact acute and long-term sequelae is essential if …
outcomes and comorbidities interact to impact acute and long-term sequelae is essential if …
Identifying genetic variants associated with chromatin looping and genome function
S Bhattacharyya, F Ay - Nature Communications, 2024 - nature.com
Here we present a comprehensive HiChIP dataset on naïve CD4 T cells (nCD4) from 30
donors and identify QTLs that associate with genotype-dependent and/or allele-specific …
donors and identify QTLs that associate with genotype-dependent and/or allele-specific …
GWAS breakthroughs: mapping the journey from one locus to 393 significant coronary artery disease associations
R Aherrahrou, T Reinberger, S Hashmi… - Cardiovascular …, 2024 - academic.oup.com
Coronary artery disease (CAD) poses a substantial threat to global health, leading to
significant morbidity and mortality worldwide. It has a significant genetic component that has …
significant morbidity and mortality worldwide. It has a significant genetic component that has …
A global high-density chromatin interaction network reveals functional long-range and trans-chromosomal relationships
Background Chromatin contacts are essential for gene-expression regulation; however,
obtaining a high-resolution genome-wide chromatin contact map is still prohibitively …
obtaining a high-resolution genome-wide chromatin contact map is still prohibitively …