“One-pot” protection, glycosylation, and protection–glycosylation strategies of carbohydrates
SS Kulkarni, CC Wang, NM Sabbavarapu… - Chemical …, 2018 - ACS Publications
Carbohydrates, which are ubiquitously distributed throughout the three domains of life, play
significant roles in a variety of vital biological processes. Access to unique and …
significant roles in a variety of vital biological processes. Access to unique and …
Toward automated enzymatic synthesis of oligosaccharides
Oligosaccharides together with oligonucleotides and oligopeptides comprise the three major
classes of natural biopolymers. Automated systems for oligonucleotide and oligopeptide …
classes of natural biopolymers. Automated systems for oligonucleotide and oligopeptide …
Automated glycan assembly: a perspective
M Guberman, PH Seeberger - Journal of the American Chemical …, 2019 - ACS Publications
The intrinsic complexity of carbohydrate structures has hampered access to pure glycans
and hence impeded progress in the glycosciences. Automated Glycan Assembly (AGA) has …
and hence impeded progress in the glycosciences. Automated Glycan Assembly (AGA) has …
Rapid phenolic O-glycosylation of small molecules and complex unprotected peptides in aqueous solvent
Glycosylated natural products and synthetic glycopeptides represent a significant and
growing source of biochemical probes and therapeutic agents. However, methods that …
growing source of biochemical probes and therapeutic agents. However, methods that …
Automated glycan assembly using the Glyconeer 2.1 synthesizer
HS Hahm, MK Schlegel, M Hurevich… - Proceedings of the …, 2017 - National Acad Sciences
Reliable and rapid access to defined biopolymers by automated DNA and peptide synthesis
has fundamentally altered biological research and medical practice. Similarly, the …
has fundamentally altered biological research and medical practice. Similarly, the …
Semi‐Synthetic Glycoconjugate Vaccine Lead Against Acinetobacter baumannii 17978
J Sianturi, P Priegue, J Hu, J Yin… - Angewandte Chemie …, 2022 - Wiley Online Library
Acinetobacter baumannii is a opportunistic bacterial pathogen responsible for serious
nosocomial infections that is becoming increasingly resistant against antibiotics. Capsular …
nosocomial infections that is becoming increasingly resistant against antibiotics. Capsular …
Chemoenzymatic synthesis of human natural killer-1-containing glycans and application as serum antibodies probes
M Bunyatov, MA Wolfert, L Liu, R Huizinga… - Nature …, 2024 - nature.com
Despite the versatility of enzyme-mediated oligosaccharide assembly, it has as a limitation
that not all glycosyl transferases or glycan-modifying enzymes are readily available to install …
that not all glycosyl transferases or glycan-modifying enzymes are readily available to install …
[HTML][HTML] Automated glycan assembly as an enabling technology
Access to complex carbohydrates remains a limiting factor for the development of the
glycosciences. Automated glycan assembly (AGA) has accelerated and simplified the …
glycosciences. Automated glycan assembly (AGA) has accelerated and simplified the …
Automated glycan assembly of oligo-N-acetyllactosamine and keratan sulfate probes to study virus-glycan interactions
HS Hahm, F Broecker, F Kawasaki, M Mietzsch… - Chem, 2017 - cell.com
Summary Oligo-N-acetyllactosamine (LacNAc) and keratan sulfate (KS) glycans exert
crucial functions in disease-relevant processes, including cancer formation, inflammation …
crucial functions in disease-relevant processes, including cancer formation, inflammation …
Recent liquid chromatographic approaches and developments for the separation and purification of carbohydrates
Carbohydrate purification remains a bottleneck in securing analytical standards from natural
sources or by chemical or enzymatic synthesis. This review highlights the scope and …
sources or by chemical or enzymatic synthesis. This review highlights the scope and …