Carbohydrates, which are ubiquitously distributed throughout the three domains of life, play
significant roles in a variety of vital biological processes. Access to unique and …

Oligosaccharides together with oligonucleotides and oligopeptides comprise the three major
classes of natural biopolymers. Automated systems for oligonucleotide and oligopeptide …

The intrinsic complexity of carbohydrate structures has hampered access to pure glycans
and hence impeded progress in the glycosciences. Automated Glycan Assembly (AGA) has …

Glycosylated natural products and synthetic glycopeptides represent a significant and
growing source of biochemical probes and therapeutic agents. However, methods that …

Reliable and rapid access to defined biopolymers by automated DNA and peptide synthesis
has fundamentally altered biological research and medical practice. Similarly, the …

Acinetobacter baumannii is a opportunistic bacterial pathogen responsible for serious
nosocomial infections that is becoming increasingly resistant against antibiotics. Capsular …

Despite the versatility of enzyme-mediated oligosaccharide assembly, it has as a limitation
that not all glycosyl transferases or glycan-modifying enzymes are readily available to install …

Access to complex carbohydrates remains a limiting factor for the development of the
glycosciences. Automated glycan assembly (AGA) has accelerated and simplified the …

Summary Oligo-N-acetyllactosamine (LacNAc) and keratan sulfate (KS) glycans exert
crucial functions in disease-relevant processes, including cancer formation, inflammation …

Carbohydrate purification remains a bottleneck in securing analytical standards from natural
sources or by chemical or enzymatic synthesis. This review highlights the scope and …