Antiphospholipid antibodies and the antiphospholipid syndrome: pathogenic mechanisms
SS Pierangeli, PP Chen, E Raschi… - … in thrombosis and …, 2008 - thieme-connect.com
Antiphospholipid antibodies (Abs) are associated with thrombosis and are a risk factor for
recurrent pregnancy loss and obstetric complications in patients with the antiphospholipid …
recurrent pregnancy loss and obstetric complications in patients with the antiphospholipid …
Haemostasis and pregnancy
M Franchini - Thrombosis and haemostasis, 2006 - thieme-connect.com
Normal pregnancy is associated with profound alterations in the coagulation and fibrinolytic
systems. While these physiological procoagulant changes are aimed to minimise …
systems. While these physiological procoagulant changes are aimed to minimise …
Serum-derived protein S binds to phosphatidylserine and stimulates the phagocytosis of apoptotic cells
HA Anderson, CA Maylock, JA Williams… - Nature …, 2003 - nature.com
Rapid phagocytosis of apoptotic cells is thought to limit the development of inflammation and
autoimmune disease. Serum enhances macrophage phagocytosis of apoptotic cells. Here …
autoimmune disease. Serum enhances macrophage phagocytosis of apoptotic cells. Here …
Hydroxychloroquine directly reduces the binding of antiphospholipid antibody–β2-glycoprotein I complexes to phospholipid bilayers
JH Rand, XX Wu, AS Quinn, PP Chen… - Blood, The Journal …, 2008 - ashpublications.org
Abstract Treatment with the antimalarial drug hydroxychloroquine (HCQ) has been
associated with reduced risk of thrombosis in the antiphospholipid (aPL) syndrome (APS) …
associated with reduced risk of thrombosis in the antiphospholipid (aPL) syndrome (APS) …
Annexin A2 mediates endothelial cell activation by antiphospholipid/anti-β2 glycoprotein I antibodies
J Zhang, KR McCrae - Blood, 2005 - ashpublications.org
Patients with antiphospholipid antibodies (APLAs) are at increased risk for arterial and
venous thrombosis. Many APLAs associated with these events react with β2 glycoprotein I …
venous thrombosis. Many APLAs associated with these events react with β2 glycoprotein I …
Platelet-endothelial interactions: sepsis, HIT, and antiphospholipid syndrome
TE Warkentin, WC Aird, JH Rand - ASH Education Program …, 2003 - ashpublications.org
Acquired abnormalities in platelets, endothelium, and their interaction occur in sepsis,
immune heparin-induced thrombocytopenia (HIT), and the antiphospholipid syndrome …
immune heparin-induced thrombocytopenia (HIT), and the antiphospholipid syndrome …
Thrombogenicity of β2-glycoprotein I–dependent antiphospholipid antibodies in a photochemically induced thrombosis model in the hamster
M Jankowski, I Vreys, C Wittevrongel… - Blood, The Journal …, 2003 - ashpublications.org
We previously showed that β2-glycoprotein I (β2GPI)–dependent lupus anticoagulants (LAs)
form bivalent antigen-antibody complexes with high affinity for phospholipids; these …
form bivalent antigen-antibody complexes with high affinity for phospholipids; these …
Human monoclonal antiphospholipid antibodies disrupt the annexin A5 anticoagulant crystal shield on phospholipid bilayers: evidence from atomic force microscopy …
JH Rand, XX Wu, AS Quinn, PP Chen… - The American journal of …, 2003 - Elsevier
The antiphospholipid (aPL) syndrome is an autoimmune condition that is marked by
recurrent pregnancy losses and/or systemic vascular thrombosis in patients who have …
recurrent pregnancy losses and/or systemic vascular thrombosis in patients who have …
Platelet-derived microparticles stimulated by anti-β2GPI/β2GPI complexes induce pyroptosis of endothelial cells in antiphospholipid syndrome
L Di, C Zha, Y Liu - Platelets, 2023 - Taylor & Francis
Platelet microparticles (PMPs) are vesicles that are released by platelets into the
extracellular space and play a role in antiphospholipid antibody syndromes. PMPs have …
extracellular space and play a role in antiphospholipid antibody syndromes. PMPs have …
[HTML][HTML] Defibrotide: properties and clinical use of an old/new drug
R Pescador, L Capuzzi, M Mantovani, A Fulgenzi… - Vascular …, 2013 - Elsevier
The drug named defibrotide (DFT) has been studied for many years. It has been shown to
possess many activities: profibrinolytic, antithrombotic–thrombolytic, antiischemic (heart …
possess many activities: profibrinolytic, antithrombotic–thrombolytic, antiischemic (heart …