Nucleic acid tests for clinical translation

M Li, F Yin, L Song, X Mao, F Li, C Fan, X Zuo… - Chemical …, 2021 - ACS Publications
Nucleic acids, including deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), are
natural biopolymers composed of nucleotides that store, transmit, and express genetic …

Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy

M Gao, F Yu, C Lv, J Choo, L Chen - Chemical Society Reviews, 2017 - pubs.rsc.org
Surgical resection of solid tumors is currently the gold standard and preferred therapeutic
strategy for cancer. Chemotherapy drugs also make a significant contribution by inhibiting …

An AIE photosensitizer with simultaneous type I and type II ROS generation: efficient bacterial elimination and hypoxic tumor ablation

Y Wang, J Liao, Y Lyu, Q Guo, Z Zhu… - Advanced Functional …, 2023 - Wiley Online Library
Aggregation induced emission (AIE) photosensitizers have attracted great attention due to
their good performance in photodynamic therapy (PDT). However, the therapeutic effect of …

Advances in targeting the folate receptor in the treatment/imaging of cancers

M Fernández, F Javaid, V Chudasama - Chemical science, 2018 - pubs.rsc.org
The folate receptor (FR) is a recognised biomarker for tumour cells due to its overexpression
on a large number of tumours. Consequently, the FR has been exploited by many diagnostic …

An Activatable Near‐Infrared Afterglow Theranostic Prodrug with Self‐Sustainable Magnification Effect of Immunogenic Cell Death

Z Gao, S Jia, H Ou, Y Hong, K Shan… - Angewandte Chemie …, 2022 - Wiley Online Library
Herein, we report an activatable near‐infrared (NIR) afterglow theranostic prodrug that
circumvents high background noise interference caused by external light excitation. The …

Theranostic fluorescent probes

A Sharma, P Verwilst, M Li, D Ma, N Singh… - Chemical …, 2024 - ACS Publications
The ability to gain spatiotemporal information, and in some cases achieve spatiotemporal
control, in the context of drug delivery makes theranostic fluorescent probes an attractive …

Recent progress on molecularly near-infrared fluorescent probes for chemotherapy and phototherapy

C Yan, Y Zhang, Z Guo - Coordination Chemistry Reviews, 2021 - Elsevier
Recently, molecularly fluorophores for nanotheranostics, bridging in vivo imaging and
therapeutic capability within unimolecular system, has attracted increasing attention …

Macrotheranostic probe with disease‐activated near‐infrared fluorescence, photoacoustic, and photothermal signals for imaging‐guided therapy

X Zhen, J Zhang, J Huang, C Xie, Q Miao… - Angewandte …, 2018 - Wiley Online Library
Theranostics provides opportunities for precision cancer therapy. However, theranostic
probes that simultaneously turn on their diagnostic signal and pharmacological action only …

Enzyme‐Engineered Conjugated Polymer Nanoplatform for Activatable Companion Diagnostics and Multistage Augmented Synergistic Therapy

J Wu, Y Zhang, K Jiang, X Wang, NT Blum… - Advanced …, 2022 - Wiley Online Library
Companion diagnostics (CDx) provides critical information for precision medicine. However,
current CDx is mostly limited to in vitro tests, which cannot accurately evaluate the disease …

Real-time tracking and in vivo visualization of β-galactosidase activity in colorectal tumor with a ratiometric near-infrared fluorescent probe

K Gu, Y Xu, H Li, Z Guo, S Zhu, S Zhu… - Journal of the …, 2016 - ACS Publications
Development of “smart” noninvasive bioimaging probes for trapping specific enzyme
activities is highly desirable for cancer therapy in vivo. Given that β-galactosidase (β-gal) is …