In all the studied mammalian species, chromatin in the germinal vesicle (GV) is initially
decondensed with the nucleolus not surrounded by heterochromatin (the NSN …

Histone modifications are associated with many fundamental biological processes in cells.
An emerging notion from recent studies is that meiosis stage-dependent histone …

Deoxynivalenol (DON) is a widespread trichothecene mycotoxin which contaminates
agricultural staples and elicits a complex spectrum of toxic effects on humans and animals. It …

Fertilization of the oocyte by the sperm results in the formation of a totipotent zygote, in which
the maternal and paternal chromatin is enclosed in two pronuclei undergoing distinct …

Benzo (a) pyrene (BaP), is an environmental pollutant present in tobacco smoke and a
byproduct of fossil fuel combustion which likely contributes to the tumorigenic processes in …

Abstract Triclocarban (TCC), a broad-spectrum lipophilic antibacterial agent, is the main
ingredient of personal and health care products. Nonetheless, its ubiquitous presence in the …

Our group and others have found that the treatment of embryos with trichostatin A (TSA) after
cloning by somatic cell nuclear transfer (SCNT) results in a significant improvement in …

Premature ovarian failure (POF), or premature ovarian insufficiency (POI), is a multifactorial
and heterogeneous disease characterized by amenorrhea, decreased estrogen levels and …

The mammalian oocyte nucleus or germinal vesicle (GV) exhibits characteristic chromatin
configurations, which are subject to dynamic modifications through oogenesis. Aim of this …

It is well established that there is a heritable element of susceptibility to chronic human
ailments, yet there is compelling evidence that some components of such heritability are …