Integrating pathways of Parkinson's disease in a molecular interaction map

KA Fujita, M Ostaszewski, Y Matsuoka, S Ghosh… - Molecular …, 2014 - Springer
Parkinson's disease (PD) is a major neurodegenerative chronic disease, most likely caused
by a complex interplay of genetic and environmental factors. Information on various aspects …

[HTML][HTML] GDNF–Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease

ER Kramer, B Liss - Febs Letters, 2015 - Elsevier
Glial cell line-derived neurotrophic factor (GDNF) and its canonical receptor Ret can signal
together or independently to fulfill many important functions in the midbrain dopaminergic …

Astrocyte-specific DJ-1 overexpression protects against rotenone-induced neurotoxicity in a rat model of Parkinson's disease

BR De Miranda, EM Rocha, Q Bai, A El Ayadi… - Neurobiology of …, 2018 - Elsevier
DJ-1 is a redox-sensitive protein with several putative functions important in mitochondrial
physiology, protein transcription, proteasome regulation, and chaperone activity. High levels …

DJ-1 as a human oncogene and potential therapeutic target

J Cao, S Lou, M Ying, B Yang - Biochemical pharmacology, 2015 - Elsevier
DJ-1 is a cancer-and Parkinson's disease-associated protein that participates in different
intracellular signaling pathways to protect cells from toxic stresses. DJ-1 expression …

SINEUPs are modular antisense long non-coding RNAs that increase synthesis of target proteins in cells

S Zucchelli, F Fasolo, R Russo, L Cimatti… - Frontiers in cellular …, 2015 - frontiersin.org
Despite recent efforts in discovering novel long non-coding RNAs (lncRNAs) and unveiling
their functions in a wide range of biological processes their applications as biotechnological …

Hypoxia signaling in parkinson's disease: There is use in asking “What HIF?”

L Lestón Pinilla, A Ugun-Klusek, S Rutella… - Biology, 2021 - mdpi.com
Simple Summary Parkinson's disease is a neurodegenerative disorder characterized by the
death of a specific subset of dopamine-producing neurons. This triggers problems with …

Dietary vitamin D deficiency in rats from middle to old age leads to elevated tyrosine nitration and proteomics changes in levels of key proteins in brain: implications for …

JTR Keeney, S Förster, R Sultana, LD Brewer… - Free Radical Biology …, 2013 - Elsevier
In addition to the well-known effects of vitamin D (VitD) in maintaining bone health, there is
increasing appreciation that this vitamin may serve important roles in other organs and …

Protective effect of hydralazine on a cellular model of Parkinson's disease: a possible role of hypoxia-inducible factor (HIF)-1α

M Mehrabani, MH Nematollahi, ME Tarzi… - … and Cell Biology, 2020 - cdnsciencepub.com
Parkinson's disease (PD) is a neurodegenerative disease accompanied by a low expression
level of cerebral hypoxia-inducible factor (HIF-1α). Hence, activating the hypoxia-signaling …

[HTML][HTML] DJ1 represses glycolysis and cell proliferation by transcriptionally upregulating pink1

R Requejo-Aguilar, I Lopez-Fabuel… - The Biochemical …, 2015 - ncbi.nlm.nih.gov
DJ1 is a multifunctional protein whose mutations cause autosomal recessive early-onset
Parkinson disease (PD). DJ1 loss of function disrupts mitochondrial function, but the …

GDNF/RET signaling in dopamine neurons in vivo

JA Conway, S Ince, S Black, ER Kramer - Cell and tissue research, 2020 - Springer
The glial cell line–derived neurotrophic factor (GDNF) and its canonical receptor Ret can
signal both in tandem and separately to exert many vital functions in the midbrain dopamine …