Simple Summary Histone deacetylase inhibitors (HDACIs) are a relatively new drug class
with important effects on the epigenetic regulation in cancer, inducing cancer cell death …

Disruption of cell cycle checkpoints has been well established as a hallmark of cancer. In
particular, the G1-S transition mediated by the cyclin D-cyclin-dependent kinase 4/6 …

Background Microglial polarization and the subsequent neuroinflammatory response are
contributing factors for traumatic brain injury (TBI)-induced secondary injury. High mobile …

Due to the complexity, aggressiveness, and heterogeneity of malignant melanoma, it is
difficult to eradicate the whole tumor through conventional treatment. Herein, a strategy of …

Protein acetylation is a reversible post-translational modification, and is involved in many
biological processes in cells, such as transcriptional regulation, DNA damage repair, and …

Malignant melanoma is the most lethal type of skin cancer with high rates of mortality.
Although current treatment options provide a short-clinical benefit, acquired-drug resistance …

Metallodrugs were classically screened against skin cancer (either in vitro or in vivo) at the
peak of the development of platinum anticancer agents. New systematic studies appeared in …

Histone deacetylases (HDACs) are a group of enzymes that regulate gene transcription by
controlling deacetylation of histones and non-histone proteins. Overexpression of HDACs is …

Abstract Low-molecular-weight (LMW) short-chain fatty acids (SCFAs), such as propionic
and butyric acids, have been reported to possess anti-neoplastic effects; however, rapid …

Background/Aim: There is a strong association between malignancy and histone
deacetylases (HDACs). Histone deacetylase inhibitors (HDACIs) are now being tested as …