This review examines the organization and translocation of Flavivirus genome RNA,
proteolytic processing of the viral polyprotein, properties of the structural and nonstructural …

On the basis of similarities in their genome organization and replication strategy, RNA
viruses can now be classified into 'supergroups' that often include both animal and plant …

In the rapidly evolving coronavirus disease (COVID-19) pandemic, repurposing existing
drugs and evaluating commercially available inhibitors against druggable targets of the virus …

A novel coronavirus has been identified as the causative agent of severe acute respiratory
syndrome (SARS). The viral main proteinase (Mpro, also called 3CLpro), which controls the …

Picornavirus RNAs are uncapped messengers and have unusually long 5'nontranslated
regions (5'NTRs) which contain many noninitiating AUG triplets. The translational efficiency …

The cleavages at the junctions of the flavivirus nonstructural (NS) proteins NS2A/NS2B,
NS2B/NS3, NS3/NS4A, and NS4B/NS5 share an amino acid sequence motif and are …

Computer-assisted comparison of the nonstructural polyprotein of hepatitis E virus (HEV)
with proteins of other positive-strand RNA viruses allowed the identification of the following …

Coronavirus genome replication and transcription take place at cytoplasmic membranes and
involve coordinated processes of both continuous and discontinuous RNA synthesis that are …

The structure of a complex between a peptide inhibitor with the sequence N-acetyl-Thr-Ile-
Nle-ψ [CH2-NH]-Nle-Gln-Arg. amide (Nle, norleucine) with chemically synthesized HIV-1 …

The dynamics of proliferation of large genomic RNA molecules which carry the polio virus
are investigated using new techniques. Genetic variation and identity conservation of …