Crop populations derived from experimental crosses enable the genetic dissection of
complex traits and support modern plant breeding. Among these, multi-parent populations …

Multi-omics allows the systematic understanding of the information flow across different
omics layers, while single omics can mainly reflect one aspect of the biological system. The …

Microbiomes play a pivotal role in plant growth and health, but the genetic factors involved in
microbiome assembly remain largely elusive. Here, we map the molecular features of the …

The challenge of precision medicine is to model complex interactions among DNA variants,
phenotypes, development, environments, and treatments. We address this challenge by …

The molecular bases of how host genetic variation impacts the gut microbiome remain
largely unknown. Here we used a genetically diverse mouse population and applied …

Today's increasingly unequal and resource intensive development model degrades and
surpasses Earth's finite capacity to sustain human well-being. Society must restore this …

Targeted proteomics enables hypothesis-driven research by measuring the cellular
expression of protein cohorts related by function, disease, or class after perturbation. Here …

In the formation of species, adaptation by natural selection generates distinct combinations
of traits that function well together. The maintenance of adaptive trait combinations in the …

Contemporary mouse genetic reference populations are a powerful platform to discover
complex disease mechanisms. Advanced high-diversity mouse populations include the …

Key message Safeguarding crop yields in a changing climate requires bioinformatics
advances in harnessing data from vast phenomics and genomics datasets to translate …