Eukaryotic cells organize their intracellular components into organelles that can be
membrane-bound or membraneless. A large number of membraneless organelles, including …

Neurodegenerative diseases are the most common causes of disability worldwide. Given
their high prevalence, devastating symptoms, and lack of definitive diagnostic tests, there is …

Long noncoding RNA (lncRNA) molecules are some of the newest and least understood
players in gene regulation. Hence, we need good model systems with well-defined RNA and …

The multiple roles played by RNA binding proteins in neurodegeneration have become
apparent following the discovery of TAR DNA binding protein 43 kDa (TDP‐43) and fused in …

Liquid-liquid phase separation of RNA-binding proteins mediates the formation of numerous
membraneless organelles with essential cellular function. However, aberrant phase …

Paraspeckles are nuclear bodies built on the long noncoding RNA Neat1, which regulates a
variety of physiological processes including cancer progression and corpus luteum …

Prion-like domains (PLDs) are low complexity sequences found in RNA binding proteins
associated with the neurodegenerative disorder amyotrophic lateral sclerosis. Recently …

Biomolecular condensation arising through phase transitions has emerged as an essential
organizational strategy that governs many aspects of cell biology. In particular, the role of …

Misfolded or mislocalized RNA‐binding proteins (RBP s) and, consequently, altered mRNA
processing, can cause neuronal dysfunction, eventually leading to neurodegeneration. Two …

The metazoan nucleus is a highly structured organelle containing several well-defined sub-
organelles. It is the largest organelle inside a cell taking up from one tenth to half of entire …