Immunoglobulin A (IgA) plays a key role in defending mucosal surfaces against attack by
infectious microorganisms. Such sites present a major site of susceptibility due to their vast …

Immunoglobulins couple the recognition of invading pathogens with the triggering of potent
effector mechanisms for pathogen elimination. Different immunoglobulin classes trigger …

The IgA receptor family comprises a number of surface receptors including the polymeric Ig
receptor involved in epithelial transport of IgA/IgM, the myeloid specific IgA Fc receptor …

Immunoglobulins (Igs) play key roles in immune protection of mucosal surfaces that form an
immense and vulnerable interface with the environment. In humans, the principal Ig in most …

Antibody therapy of cancer is increasingly used in the clinic and has improved patient's life
expectancy. Except for immune checkpoint inhibition, the mode of action of many antibodies …

Abstract Immunoglobulin-α (IgA)-bound antigens induce immune effector responses by
activating the IgA-specific receptor FcαRI (CD89) on immune cells. Here we present crystal …

IgA has traditionally been regarded a non-inflammatory antibody. This might indeed be true
for secretory IgA (SIgA), which exerts its function at mucosal surfaces where commensal …

The pathogenesis of immunoglobulin A (IgA) nephropathy (IgAN), the most prevalent form of
glomerulonephritis worldwide, involves circulating macromolecular IgA1 complexes …

Immunoglobulin A (IgA) is commonly recognized as the most prevalent antibody (Ab) at
mucosal sites with an important role in defense by shielding mucosal surfaces from invasion …

The staphylococcal superantigen-like proteins (SSLs) are close relatives of the
superantigens but are coded for by a separate gene cluster within a 19-kb region of the …