There is significant interest in understanding inflammatory responses within the brain and
spinal cord. Inflammatory responses that are centralized within the brain and spinal cord are …

Neuroinflammation has become a key hallmark of neurological complications including
perioperative pathologies such as postoperative delirium and longer-lasting postoperative …

Neuroinflammation is central to the common pathology of several acute and chronic brain
diseases. This review examines the consequences of excessive and prolonged …

Resident microglial cells can be regarded as the immunological watchdogs of the brain and
the retina. They are active sensors of their neuronal microenvironment and rapidly respond …

Abstract Post-Operative Cognitive Dysfunction (POCD) is a highly prevalent condition with
significant clinical, social and financial impacts for patients and their communities. The …

Innate immunity within the central nervous system (CNS) is primarily provided by resident
microglia. Microglia are pivotal in immune surveillance and also facilitate the co‐ordinated …

Surgery can induce cognitive decline, a risk that increases with advancing age. In rodents,
postoperative cognitive decline (POCD) is associated with the inflammatory activation of …

Microglia are critical nervous system-specific cells influencing brain development,
maintenance of the neural environment, response to injury, and repair. They contribute to …

Ever since Bedford's 1 seminal Lancet case series in 1955, we have known that
perioperative care is sometimes followed by significant cognitive dysfunction. Although the …

Objective: Although postoperative cognitive dysfunction (POCD) often complicates recovery
from major surgery, the pathogenic mechanisms remain unknown. We explored whether …