Ca2+ dynamics in interstitial cells: foundational mechanisms for the motor patterns in the gastrointestinal tract

KM Sanders, BT Drumm, CA Cobine… - Physiological …, 2024 - journals.physiology.org
The gastrointestinal (GI) tract displays multiple motor patterns that move nutrients and
wastes through the body. Smooth muscle cells (SMCs) provide the forces necessary for GI …

Possible beneficial actions of caffeine in SARS-CoV-2

BS Romero-Martinez, LM Montano… - International Journal of …, 2021 - mdpi.com
The COVID-19 pandemic has established an unparalleled necessity to rapidly find effective
treatments for the illness; unfortunately, no specific treatment has been found yet. As this is a …

Inhibitors of L-type calcium channels show therapeutic potential for treating SARS-CoV-2 infections by preventing virus entry and spread

MR Straus, MK Bidon, T Tang, JA Jaimes… - ACS Infectious …, 2021 - ACS Publications
COVID-19 is caused by a novel coronavirus, the severe acute respiratory syndrome
coronavirus (CoV)-2 (SARS-CoV-2). The virus is responsible for an ongoing pandemic and …

FDA approved calcium channel blockers inhibit SARS-CoV-2 infectivity in epithelial lung cells

MR Straus, M Bidon, T Tang, GR Whittaker, S Daniel - BioRxiv, 2020 - biorxiv.org
COVID-19 has infected more than 41 million people worldwide with over 1.1 million deaths
and is caused by the severe acute respiratory syndrome coronavirus (CoV) 2 (SARS-CoV …

Prolactin-induced neuroprotection against glutamate excitotoxicity is mediated by the reduction of [Ca2+]i overload and NF-κB activation

NA Rivero-Segura, E Flores-Soto… - PloS one, 2017 - journals.plos.org
Prolactin (PRL) is a peptidic hormone that displays pleiotropic functions in the organism
including different actions in the brain. PRL exerts a neuroprotective effect against …

Could lower testosterone in older men explain higher COVID-19 morbidity and mortalities?

LM Montano, B Sommer, H Solis-Chagoyan… - International Journal of …, 2022 - mdpi.com
The health scourge imposed on humanity by the COVID-19 pandemic seems not to recede.
This fact warrants refined and novel ideas analyzing different aspects of the illness. One …

Store‐operated calcium entry is required for sustained contraction and Ca2+ oscillations of airway smooth muscle

J Chen, MJ Sanderson - The Journal of physiology, 2017 - Wiley Online Library
Key points Airway hyper‐responsiveness in asthma is driven by excessive contraction of
airway smooth muscle cells (ASMCs). Agonist‐induced Ca2+ oscillations underlie this …

Estrogen receptors differentially regulate intracellular calcium handling in human nonasthmatic and asthmatic airway smooth muscle cells

S Bhallamudi, J Connell, CM Pabelick… - … of Physiology-Lung …, 2020 - journals.physiology.org
Asthma is defined as chronic inflammation of the airways and is characterized by airway
remodeling, hyperresponsiveness, and acute bronchoconstriction of airway smooth muscle …

Acute cigarette smoke or extract exposure rapidly activates TRPA1-mediated calcium influx in primary human airway smooth muscle cells

JH Lin, M Taggart, L Borthwick, A Fisher, M Brodlie… - Scientific Reports, 2021 - nature.com
Tobacco smoking is the largest risk factor for developing chronic obstructive pulmonary
disease (COPD), and is associated with hyperresponsiveness of airway smooth muscle …

Estrogenic modulation of ionic channels, pumps and exchangers in Airway smooth muscle

BS Romero-Martínez, B Sommer… - International Journal of …, 2023 - mdpi.com
To preserve ionic homeostasis (primarily Ca2+, K+, Na+, and Cl−), in the airway smooth
muscle (ASM) numerous transporters (channels, exchangers, and pumps) regulate the influx …