Haemodynamic, metabolic, and biochemical derangements in critically ill patients affect
drug pharmacokinetics and pharmacodynamics making dose optimisation particularly …

Background Regardless of the available antifungals, intraabdominal candidiasis (IAC)
mortality continues to be high and represents a challenge for clinicians. Main body This …

Data of developmental pharmacokinetics (PK) of meropenem in critically ill infants and
children with severe infections are limited. We assessed the population PK and defined the …

Levetiracetam is a broad-spectrum antiepileptic drug commonly used in intensive care units
(ICUs). The objective of this study is to evaluate the adequacy of levetiracetam dosing in …

Assessment of glomerular filtration rate (GFR) is necessary for dose adjustments of beta-
lactam that are excreted by the kidneys, such as meropenem. The aim of this study was to …

Background Levetiracetam pharmacokinetics is extensively altered in critically ill patients
with augmented renal clearance (ARC). Consequently, the dosage regimens commonly …

Status epilepticus is a common neurological emergency, with overall mortality around 20%.
Over half of cases are first time presentations of seizures. The pathological process by which …

The present study assessed the proportion of intensive care unit (ICU) patients who had a
vancomycin serum concentration between 20 and 25 mg/L after 24–48 h of intravenous …

Augmented renal clearance (ARC), defined as a creatinine clearance (CrCl)> 130
mL/min/1.73 m2, is observed in 30–65% of critically ill patients. When following standard …

Vancomycin is an antibiotic that is used to treat gram-positive infections in critically ill adults.
For continuously administered vancomycin (CI), various target ranges have been used in the …