Free radical scavenging, antibacterial potentials and spectroscopic characterizations of benzoyl thiourea derivatives and their metal complexes

HUR Shah, K Ahmad, M Ashfaq, H Oku - Journal of Molecular Structure, 2023 - Elsevier
In this work, two series of benzoyl thiourea derivatives (TH01-TH05),(TH06-TH10) and their
metal complexes were successfully synthesized in good yields (up to 90%) using efficient …

Synthesis and Biological Importance of 2-(thio) ureabenzothiazoles

MC Rosales-Hernández, JE Mendieta-Wejebe… - Molecules, 2022 - mdpi.com
The (thio) urea and benzothiazole (BT) derivatives have been shown to have a broad
spectrum of biological activities. These groups, when bonded, result in the 2-(thio) …

Synthesis of isoniazid analogs with promising antituberculosis activity and bioavailability: biological evaluation and computational studies

R Gavadia, J Rasgania, MV Basil, V Chauhan… - Journal of Molecular …, 2023 - Elsevier
A series of aliphatic isoniazid carbo (x/thio) amides has been synthesized by a facile one-pot
green method in aqueous media by harnessing microwave irradiations. In vitro …

Facile synthesis, pharmacological and In silico analysis of succinimide derivatives: An approach towards drug discovery

J Rasgania, R Gavadia, K Jakhar - Journal of Molecular Structure, 2023 - Elsevier
The hybrid heterocyclic scaffolds possess extensive medicinal values and significant
pharmaceutical usage. A series of N-substituted-2, 5-dioxopyrrolidine carboxamides …

Synthesis of Novel N-Methylmorpholine-Substituted Benzimidazolium Salts as Potential α-Glucosidase Inhibitors

IA Khan, FA Saddique, S Aslam, UA Ashfaq, M Ahmad… - Molecules, 2022 - mdpi.com
The α-glucosidase enzyme, located in the brush border of the small intestine, is responsible
for overall glycemic control in the body. It hydrolyses the 1, 4-linkage in the carbohydrates to …

Contribution to the Synthesis, Characterization, Separation and Quantification of New N-Acyl Thiourea Derivatives with Antimicrobial and Antioxidant Potential

R Roman, L Pintilie, DC Nuță, MT Căproiu… - Pharmaceutics, 2023 - mdpi.com
The present study aimed to synthesize, characterize, and validate a separation and
quantification method of new N-acyl thiourea derivatives (1a–1o), incorporating thiazole or …

Synthesis, analgesic, anti-inflammatory, COX/5-LOX inhibition, ulcerogenic evaluation, and docking study of benzimidazole bearing indole and benzophenone …

KMJ Nagesh, T Prashanth, HA Khamees… - Journal of Molecular …, 2022 - Elsevier
Inflammation therapy is particularly focused on the development of safer non-steroidal anti-
inflammatory drugs (NSAIDs), administered to control inflammation. It is typically considered …

N-substitution reactions of 2-aminobenzimidazoles to access pharmacophores

II Padilla-Martínez, A Cruz… - Current Organic …, 2023 - ingentaconnect.com
Benzimidazole (BI) and its derivatives are interesting molecules in medicinal chemistry
because several of these compounds have a diversity of biological activities and some of …

Synthesis and antitumor evaluation of menthone-derived pyrimidine-urea compounds as potential PI3K/Akt/mTOR signaling pathway inhibitor

M Huang, W Duan, N Chen, G Lin, X Wang - Frontiers in Chemistry, 2022 - frontiersin.org
A series of novel menthone derivatives bearing pyrimidine and urea moieties was designed
and synthesized to explore more potent natural product-derived antitumor agents. The …

Synthesis of thiazole-based-thiourea analogs: as anticancer, antiglycation and antioxidant agents, structure activity relationship analysis and docking study

M Taha, F Rahim, IU Khan, N Uddin… - Journal of …, 2023 - Taylor & Francis
This work reports the convenient approach for the synthesis of thiazole based thiourea
derivatives (1-21) from 2-bromo-1-(4-fluorophenyl) thiazole-1-one and phenyl …